A convenient one-pot preparative method for 4,5-diarylisoxazoles involving amine exchange reactions

被引：83

作者：

Dominguez, E

Ibeas, E

deMarigorta, EM

Palacios, JK

SanMartin, R

机构：

[1] Kimika Organikoa Saila, Euskal Herriko Unibertsitatea, 48080 Bilbo

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1996年 / 61卷 / 16期

关键词：

D O I：

10.1021/jo960024h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

4,5-Diarylisoxazoles 1 are efficiently prepared by submitting enaminones 2, readily obtained from deoxybenzoins 3, to oximation conditions. This conversion implies an uncommon amine group exchange reaction. Preparation of 4-isoxazolines 5 and ring-opening transformations to beta-keto nitriles 4 and 1,3-amino alcohol derivatives 7 are also described.

引用

页码：5435 / 5439

页数：5

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