Antimalarial activity of 20 crude extracts from nine African medicinal plants used in Kinshasa, Congo

被引:121
作者
Tona, L
Ngimbi, NP
Tsakala, M
Mesia, K
Cimanga, K
Apers, S
De Bruyne, T
Pieters, L
Totté, J
Vlietinck, AJ
机构
[1] Univ Kinshasa, Fac Pharm, Kinshasa 11, DEM REP CONGO
[2] Inst Trop Med, Fac Med, Kinshasa 11, DEM REP CONGO
[3] Univ Instelling Antwerp, Dept Pharmaceut Sci, B-2610 Antwerp, Belgium
关键词
plant extracts; antiplasmodial; malaria; traditional medicine; Congo-Kinshasa;
D O I
10.1016/S0378-8741(99)00090-2
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Twenty extracts including ten EtOH and ten CH2Cl2 from different parts of nine African medicinal plants used in Congolese traditional medicine for the treatment of malaria, were submitted to a pharmacological test in order to evaluate their effect on P. falciparum growth in vitro. Of these plant species, 14 (70%) extracts including EtOH and CH2Cl2 from Cassia occidentalis leaves, Cryptolepis sanguinolenta root bark, Euphorbia hirta whole plant, Garcinia kola stem bark and seeds, Morinda lucida leaves and Phyllanthus niruri whole plant produced more than 60% inhibition of the parasite growth in vitro at a test concentration of 6 mu g/ml. Extracts from E. hirta, C. sanguinolenta and M. morindoides showed a significant chemosuppression of parasitaemia in mice infected with P. berghei berghei at orally given doses of 100-400 mg/kg per day. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:193 / 203
页数:11
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