Comparative study of transfection efficiency of cationic cholesterols mediated by liposomes-based gene delivery

被引：38

作者：

Hasegawa, S ^{[1
]}

Hirashima, N ^{[1
]}

Nakanishi, M ^{[1
]}

机构：

[1] Nagoya City Univ, Grad Sch Pharmaceut Sci, Mizuho Ku, Nagoya, Aichi 4678603, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 09期

关键词：

D O I：

10.1016/S0960-894X(02)00119-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

To develop the efficient non-viral vector for gene delivery, we compared transfection activities of cationic cholesterol derivatives. We found that the stability of the liposome-DNA complex in the presence of endosome deeply related to the transfection efficiency. We also found that the introduction of a hydrophilic group to the amino terminal of the cholesterol derivative decreased stability and facilitated the release of DNA from the endosome, resulting in higher transfection efficiency. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：1299 / 1302

页数：4

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