Nitrogen and sulfur analogues of the seco-CO alkylating agent: Synthesis and cytotoxicity

被引：15

作者：

Tercel, M ^{[1
]}

Denny, WA ^{[1
]}

Wilson, WR ^{[1
]}

机构：

[1] UNIV AUCKLAND,DEPT PATHOL,SECT ONCOL,AUCKLAND 1,NEW ZEALAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 22期

关键词：

D O I：

10.1016/S0960-894X(96)00507-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The first synthesis of seca-CI alkylating agents bearing a nitrogen or sulfur substituent in place of the oxygen at C-6 is described. In comparison with a phenol, an amino substituent confers reduced but significant cytotoxicity, even when mono- or dimethylated, while sulfur analogues are considerably less potent. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：2735 / 2740

页数：6

共 21 条

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