ROLE OF THE CC-1065 AND DUOCARMYCIN N-2 SUBSTITUENT - VALIDATION OF A DIRECT RELATIONSHIP BETWEEN SOLVOLYSIS CHEMICAL-STABILITY AND IN-VITRO BIOLOGICAL POTENCY

被引：76

作者：

BOGER, DL

YUN, WY

机构：

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1994年 / 116卷 / 12期

关键词：

D O I：

10.1021/ja00091a088

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

引用

收藏

页码：5523 / 5524

页数：2

相关论文

共 41 条

[1] Boger D L, 1993, Bioorg Med Chem, V1, P27, DOI 10.1016/S0968-0896(00)82100-8
[2] Boger D L, 1994, Bioorg Med Chem, V2, P115, DOI 10.1016/S0968-0896(00)82007-6
[3] Boger D. L., 1991, CHEMTRACTS ORG CHEM, V4, P329
[4] DEMONSTRATION OF A PRONOUNCED EFFECT OF NONCOVALENT BINDING SELECTIVITY ON THE (+)-CC-1065 DNA ALKYLATION AND IDENTIFICATION OF THE PHARMACOPHORE OF THE ALKYLATION SUBUNIT
BOGER, DL
ZARRINMAYEH, H
MUNK, SA
KITOS, PA
SUNTORNWAT, O
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (04) : 1431 - 1435
[5] REVERSIBILITY OF THE DUOCARMYCIN-A AND SA DNA ALKYLATION REACTION
BOGER, DL
YUN, WY
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1993, 115 (21) : 9872 - 9873
[6] (+)-CC-1065 DNA ALKYLATION - KEY STUDIES DEMONSTRATING A NONCOVALENT BINDING SELECTIVITY CONTRIBUTION TO THE ALKYLATION SELECTIVITY
BOGER, DL
MUNK, SA
ZARRINMAYEH, H
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1991, 113 (10) : 3980 - 3983
[7] SYNTHESIS OF N-(TERT-BUTYLOXYCARBONYL)-CBI, CBI, CBI-CDPI1, AND CBI-CDPI2 - ENHANCED FUNCTIONAL ANALOGS OF CC-1065 INCORPORATING THE 1,2,9,9A-TETRAHYDROCYCLOPROPA[C]BENZ[E]INDOL-4-ONE (CBI) LEFT-HAND SUBUNIT
BOGER, DL
ISHIZAKI, T
KITOS, PA
SUNTORNWAT, O
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1990, 55 (23) : 5823 - 5832
[8] BOGER DL, 1991, HETEROCYCLES IN BIO-ORGANIC CHEMISTRY, P103
[9] RESOLUTION OF A CBI PRECURSOR AND INCORPORATION INTO THE SYNTHESIS OF (+)-CBI, (+)-CBI-CDPI1, (+)-CBI-CDPI2 - ENHANCED FUNCTIONAL ANALOGS OF (+)-CC-1065 - A CRITICAL-APPRAISAL OF A PROPOSED RELATIONSHIP BETWEEN ELECTROPHILE REACTIVITY, DNA-BINDING PROPERTIES, AND CYTOTOXIC POTENCY
BOGER, DL
ISHIZAKI, T
[J]. TETRAHEDRON LETTERS, 1990, 31 (06) : 793 - 796
[10] SYNTHESIS AND PRELIMINARY EVALUATION OF AGENTS INCORPORATING THE PHARMACOPHORE OF THE DUOCARMYCIN PYRINDAMYCIN ALKYLATION SUBUNIT - IDENTIFICATION OF THE CC-1065 DUOCARMYCIN COMMON PHARMACOPHORE
BOGER, DL
ISHIZAKI, T
ZARRINMAYEH, H
KITOS, PA
SUNTORNWAT, O
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1990, 55 (15) : 4499 - 4502

← 1 2 3 4 5 →