Positive selection of T cells induced by viral delivery of neopeptides to the thymus

被引：98

作者：

Nakano, N

Rooke, R

Benoist, C

Mathis, D

机构：

[1] INSERM, CNRS, Universite Louis Pasteur, 67404 Illkirch, C.U. de Strasbourg

来源：

SCIENCE | 1997年 / 275卷 / 5300期

关键词：

D O I：

10.1126/science.275.5300.678

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The relation between an antigenic peptide that can stimulate a mature T cell and the natural peptide that promoted selection of this cell in the thymus is still unknown. An experimental system was devised to address this issue in vivo-mice expressing neopeptides in thymic stromal cells after adenovirus-mediated delivery of invariant chain-peptide fusion proteins. In this system, selection of T cells capable of responding to a given antigenic peptide could be promoted by the peptide itself, by closely related analogs lacking agonist and antagonist activity, or by ostensibly unrelated peptides. However, the precise repertoire of T cells selected was dictated by the particular neopeptide expressed.

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页码：678 / 683

页数：6

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