Treatment of obstructive airway disease with a cysteine donor protein supplement - A case report

被引:14
作者
Lothian, B
Grey, V
Kimoff, RJ
Lands, LC
机构
[1] McGill Univ, Montreal Childrens Hosp, Ctr Hlth, Div Resp Med, Montreal, PQ H3H 1P3, Canada
[2] McGill Univ, Montreal Childrens Hosp, Ctr Hlth, Dept Pediat, Montreal, PQ H3H 1P3, Canada
[3] McGill Univ, Montreal Childrens Hosp, Ctr Hlth, Dept Biochem, Montreal, PQ H3H 1P3, Canada
[4] McGill Univ, Ctr Hlth, Royal Victoria Hosp, Div Resp Med, Montreal, PQ, Canada
关键词
glutathione; inflammation; oxidative stress; supplementation;
D O I
10.1378/chest.117.3.914
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Oxidant/antioxidant imbalance can occur in obstructive airways disease as a result of ongoing inflammation. Glutathione (CSH) plays a major role in pulmonary antioxidant protection. As an alternative or complement to anti-inflammatory therapy, augmenting antioxidant protection could diminish the effects of inflammation. We describe a case of a patient who had obstructive lung disease responsive to corticosteroids, and low whole blood GSW levels. After 1 month of supplementation with a whey-based oral supplement designed to provide GSH precursors, whole blood GSH levels and pulmonary function increased significantly and dramatically. The potential for such supplementation in pulmonary inflammatory conditions deserves further study.
引用
收藏
页码:914 / 916
页数:3
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