Comprehensive elaboration of glycemic variability in diabetic macrovascular and microvascular complications

被引：150

作者：

Sun, Bao ^{[1
,2
]}

Luo, Zhiying ^{[1
,2
]}

Zhou, Jiecan ^{[3
]}

机构：

[1] Cent South Univ, Xiangya Hosp 2, Dept Pharm, 139 Middle Renmin Rd, Changsha 410011, Hunan, Peoples R China

[2] Cent South Univ, Inst Clin Pharm, Changsha 410011, Peoples R China

[3] Univ South China, Affiliated Hosp 1, Inst Clin Med, 69 Chuanshan Rd, Hengyang 421001, Hunan, Peoples R China

来源：

CARDIOVASCULAR DIABETOLOGY | 2021年 / 20卷 / 01期

关键词：

Glycemic variability; Diabetes mellitus; Diabetic macrovascular and microvascular complications; Therapeutic strategies; FASTING PLASMA-GLUCOSE; TO-VISIT VARIABILITY; CHRONIC KIDNEY-DISEASE; ALL-CAUSE MORTALITY; OXIDATIVE STRESS; HBA1C VARIABILITY; PERIPHERAL NEUROPATHY; BLOOD-PRESSURE; RISK-FACTORS; VASCULAR COMPLICATIONS;

D O I：

10.1186/s12933-020-01200-7

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Diabetes mellitus is the major risk factor for the development of macrovascular and microvascular complications. It is increasingly recognized that glycemic variability (GV), referring to oscillations in blood glucose levels and representing either short-term or long-term GV, is involved in the pathogenesis of diabetic complications and has emerged as a possible independent risk factor for them. In this review, we summarize the metrics and measurement of GV in clinical practice, as well as comprehensively elaborate the role and related mechanisms of GV in diabetic macrovascular and microvascular complications, aiming to provide the mechanism-based therapeutic strategies for clinicians to manage diabetes mellitus.

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页数：13

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