Catalytic asymmetric synthesis of glutamate analogues

被引：14

作者：

Burkhart, DJ

McKenzie, AR

Nelson, JK

Myers, KI

Zhao, X

Magnusson, KR

Natale, NR

机构：

[1] Univ Idaho, Dept Chem, Moscow, ID 83844 USA

[2] Univ Idaho, Dept Biol Sci, Moscow, ID 83844 USA

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 08期

关键词：

D O I：

10.1021/ol049619m

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Utilizing our lateral metalation coupled with Jacobsen's catalytic asymmetric amino nitrile synthesis, we have demonstrated the ability to synthesize isoxazole-containing amino acid glutamate analogues in high yield and high enantiomeric excesses. Chiral centers alpha or beta at the C-5 position do not detract from diastereoselectivity of the Jacobsen-Strecker reaction.

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页码：1285 / 1288

页数：4

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