A biomimetic route to the peptide alkaloid anachelin

被引：36

作者：

Gademann, K ^{[1
]}

Bethuel, Y ^{[1
]}

机构：

[1] ETH Honggerberg, Organ Chem Lab, CH-8093 Zurich, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 25期

关键词：

alkaloids; biomimetic syntheses; natural products; peptides; polyketides;

D O I：

10.1002/anie.200453909

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A postulated biogenesis forms the basis for a synthetic route to the natural product anachelin H (1). Key steps include a tellurium-mediated, oxidative aza annulation and a Claisen condensation under mild conditions. Experiments with a model substrate indicate that it is likely that a catechol oxidase-type enzyme is involved in the biosynthesis of the anachelin chromophore.

引用

页码：3327 / 3329

页数：3

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