Nitrogen heterocycles via palladium-catalyzed carbocyclization.: Formal synthesis of (+)-α-allokainic acid

被引：27

作者：

Cook, GR ^{[1
]}

Sun, LD ^{[1
]}

机构：

[1] N Dakota State Univ, Dept Chem & Mol Biol, Ctr Protease Res, Fargo, ND 58105 USA

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 14期

关键词：

D O I：

10.1021/ol049087+

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Pd-catalyzed carbocyclization of ketoamides was investigated and found to be highly dependent on the phosphine ligand as well as the presence of coordinating counterions. Nitrogen heterocycles were formed without erosion of the stereochemical integrity. The utility of the lactam products was demonstrated by the formal synthesis of (+)-alpha-allokainic acid.

引用

页码：2481 / 2484

页数：4

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