Using genetic variation to study immunomodulation

被引：9

作者：

Chanock, S ^{[1
]}

Taylor, JG ^{[1
]}

机构：

[1] NCI, Sect Genom Variat, Pediat Oncol Branch, Ctr Adv Technol, Gaithersburg, MD 20877 USA

来源：

CURRENT OPINION IN PHARMACOLOGY | 2002年 / 2卷 / 04期

关键词：

D O I：

10.1016/S1471-4892(02)00186-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The generation of a draft sequence of a human genome has led to the identification of millions of common variants, known as single nucleotide polymorphisms, which constitute a resource for studying complex diseases. Currently, high-density maps of variants in candidate genes, chromosomal regions or the entire genome should encourage investigation of determinants of human immune response, using quantitative analysis. Ultimately, this approach should identify novel targets for therapeutic intervention.

引用

页码：463 / 469

页数：7

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