Dendrite growth increased by visual activity requires NMDA receptor and Rho GTPases

被引：353

作者：

Sin, WC ^{[1
]}

Haas, K ^{[1
]}

Ruthazer, ES ^{[1
]}

Cline, HT ^{[1
]}

机构：

[1] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA

来源：

NATURE | 2002年 / 419卷 / 6906期

关键词：

D O I：

10.1038/nature00987

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Previous studies suggest that neuronal activity may guide the development of synaptic connections in the central nervous system through mechanisms involving glutamate receptors and GTPase-dependent modulation of the actin cytoskeleton(1-7). Here we demonstrate by in vivo time-lapse imaging of optic tectal cells in Xenopus laevis tadpoles that enhanced visual activity driven by a light stimulus promotes dendritic arbor growth. The stimulus-induced dendritic arbor growth requires glutamate-receptor-mediated synaptic transmission, decreased RhoA activity and increased Rac and Cdc42 activity. The results delineate a role for Rho GTPases in the structural plasticity driven by visual stimulation in vivo.

引用

页码：475 / 480

页数：6

共 30 条

[1] Cellular and molecular features of axon collaterals and dendrites [J].

Acebes, A ;

Ferrús, A .

TRENDS IN NEUROSCIENCES, 2000, 23 (11) :557-565

[2] Overexpression of a neural-specific Rho family GTPase, cRac1B, selectively induces enhanced neuritogenesis and neurite branching in primary neurons [J].

Albertinazzi, C ;

Gilardelli, D ;

Paris, S ;

Longhi, R ;

de Curtis, I .

JOURNAL OF CELL BIOLOGY, 1998, 142 (03) :815-825

[3] Effectors for the Rho GTPases [J].

Aspenström, P .

CURRENT OPINION IN CELL BIOLOGY, 1999, 11 (01) :95-102

[4] Oligophrenin-1 encodes a rhoGAP protein involved in X-linked mental retardation [J].

Billuart, P ;

Bienvenu, T ;

Ronce, N ;

Des Portes, V ;

Vinet, MC ;

Zemni, R ;

Roest Crollius, H ;

Carrié, A ;

Fauchereau, F ;

Cherry, M ;

Briault, S ;

Hamel, B ;

Fryns, JP ;

Beldjord, C ;

Kahn, A ;

Moraine, C ;

Chelly, J .

NATURE, 1998, 392 (6679) :923-926

[5] A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM kinase II [J].

Chen, HJ ;

Rojas-Soto, M ;

Oguni, A ;

Kennedy, MB .

NEURON, 1998, 20 (05) :895-904

[6] The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains [J].

Debant, A ;

SerraPages, C ;

Seipel, K ;

OBrien, S ;

Tang, M ;

Park, SH ;

Streuli, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (11) :5466-5471

[7] Inhibition of calcium release-activated calcium current by Rac/Cdc42-inactivating clostridial cytotoxins in RBL cells [J].

Djouder, N ;

Prepens, U ;

Aktories, K ;

Cavalié, A .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (25) :18732-18738

[8] Dendritic spine changes associated with hippocampal long-term synaptic plasticity [J].

Engert, F ;

Bonhoeffer, T .

NATURE, 1999, 399 (6731) :66-70

[9] Glutamate receptors regulate actin-based plasticity in dendritic spines [J].

Fischer, M ;

Kaech, S ;

Wagner, U ;

Brinkhaus, H ;

Matus, A .

NATURE NEUROSCIENCE, 2000, 3 (09) :887-894

[10] Citron, a Rho-target, interacts with PSD-95/SAP-90 at glutamatergic synapses in the thalamus [J].

Furuyashiki, T ;

Fujisawa, K ;

Fujita, A ;

Madaule, P ;

Uchino, S ;

Mishina, M ;

Bito, H ;

Narumiya, S .

JOURNAL OF NEUROSCIENCE, 1999, 19 (01) :109-118

← 1 2 3 →