Amide bond formation: beyond the myth of coupling reagents

被引：1868

作者：

Valeur, Eric ^{[1
]}

Bradley, Mark ^{[1
]}

机构：

[1] Univ Edinburgh, Sch Chem, Edinburgh EH9 3JJ, Midlothian, Scotland

来源：

CHEMICAL SOCIETY REVIEWS | 2009年 / 38卷 / 02期

关键词：

PHASE PEPTIDE-SYNTHESIS; BENZOTRIAZOL-1-YL DIETHYL PHOSPHATE; N-HYDROXYSUCCINIMIDE ESTERS; MIXED ANHYDRIDE METHOD; ALPHA-AMINO-ACIDS; HIGHLY EFFICIENT; DIPHENYL PHOSPHATE; CARBOXYLIC-ACIDS; ONE-POT; CONVENIENT REAGENT;

D O I：

10.1039/b701677h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Amide bond formation is a fundamentally important reaction in organic synthesis, and is typically mediated by one of a myriad of so-called coupling reagents. This critical review is focussed on the most recently developed coupling reagents with particular attention paid to the pros and cons of the plethora of "acronym'' based reagents. It aims to demystify the process allowing the chemist to make a sensible and educated choice when carrying out an amide coupling reaction (179 references).

引用

页码：606 / 631

页数：26

共 181 条

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