An exopolysaccharide produced by Geobacillus thermodenitrificans strain B3-72: Antiviral activity on immunocompetent cells

被引：111

作者：

Arena, Adriana ^{[2
]}

Gugliandolo, Concetta ^{[3
]}

Stassi, Giovanna ^{[2
]}

Pavone, Bernadette ^{[2
]}

Iannello, Daniela ^{[2
]}

Bisignano, Giuseppe ^{[1
]}

Maugeri, Teresa Luciana ^{[3
]}

机构：

[1] Univ Messina, Pharmacobiol Dept, I-98168 Messina, Italy

[2] Univ Messina, Dept Surg Sci, Microbiol Unit, I-98125 Messina, Italy

[3] Univ Messina, Dept Anim Biol & Marine Ecol, I-98166 Messina, Italy

来源：

IMMUNOLOGY LETTERS | 2009年 / 123卷 / 02期

关键词：

Anti-HSV-2; activity; Exopolysaccharide; Immunomodulatory effect; Thermophilic bacilli; HERPES-SIMPLEX-VIRUS; SEA HYDROTHERMAL VENT; SULFATED POLYSACCHARIDES; CYTOKINE PRODUCTION; MARINE; BACTERIUM; SHALLOW; IL-4; INTERLEUKIN-4; ACTIVATION;

D O I：

10.1016/j.imlet.2009.03.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

The immunomodulatory and antiviral effects of an extracellular polysaccharide (EPS-2), produced by a strain of Geobacillus thermodenitrificans isolated from a shallow marine vent of Vulcano Island (Italy), were evaluated. In the present study, we show for the first time that EPS-2 treatment hinder HSV-2 replication in human peripheral blood mononuclear cells (PBMC) but not in WISH cells. In fact, high levels of IFN-alpha, IL-12, IFN-gamma, TNF-alpha, IL-18 were detected in supernatants of EPS-2 treated PBMC. Moreover, this effect was dose-dependent. Taken together, our results confirm that the immunological disorders determined by HSV-2 could be partially restored by treatment with EPS-2. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：132 / 137

页数：6

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