Flexible, palladium-catalyzed indole and azaindole synthesis by direct annulation of chloroanilines and chloroaminopyridines with ketones

被引：123

作者：

Nazaré, M ^{[1
]}

Schneider, C ^{[1
]}

Lindenschmidt, A ^{[1
]}

Will, DW ^{[1
]}

机构：

[1] Aventis Pharma Deutschland GmbH, DI&A Chem, D-65926 Frankfurt, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 34期

关键词：

annulation; cyclization; indoles; nitrogen heterocycles; palladium;

D O I：

10.1002/anie.200460122

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The ringmaster" [Pd(tBu3P)2] serves as the catalyst in the direct synthesis of indoles by annulation of ortho-chloroanilines with ketones (see picture). This versatile method can be used to synthesize a variety of functionalized indoles and azaindoles. DMA = dimethylacetarnide."

引用

页码：4526 / 4528

页数：3

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