Consistent Detection of 2019 Novel Coronavirus in Saliva

被引：1212

作者：

To, Kelvin Kai-Wang ^{[1
,2
,3
]}

Tsang, Owen Tak-Yin ^{[4
]}

Yip, Cyril Chik-Yan ^{[1
,2
]}

Chan, Kwok-Hung ^{[1
]}

Wu, Tak-Chiu ^{[5
]}

Chan, Jacky Man-Chun ^{[4
]}

Leung, Wai-Shing ^{[4
]}

Chik, Thomas Shiu-Hong ^{[4
]}

Choi, Chris Yau-Chung ^{[4
]}

Kandamby, Darshana H. ^{[6
]}

Lung, David Christopher ^{[7
]}

Tam, Anthony Raymond ^{[8
]}

Poon, Rosana Wing-Shan ^{[1
,2
]}

Fung, Agnes Yim-Fong ^{[1
]}

Hung, Ivan Fan-Ngai ^{[8
]}

Cheng, Vincent Chi-Chung ^{[1
,2
]}

Chan, Jasper Fuk-Woo ^{[1
,2
,3
]}

Yuen, Kwok-Yung ^{[1
,2
,3
]}

机构：

[1] Univ Hong Kong, Li Ka Shing Fac Med, State Key Lab Emerging Infect Dis, Dept Microbiol,Carol Yu Ctr Infect, Hong Kong, Peoples R China

[2] Queen Mary Hosp, Dept Microbiol, Hong Kong, Peoples R China

[3] Univ Hong Kong, Dept Clin Microbiol & Infect Control, Shenzhen Hosp, Shenzhen, Peoples R China

[4] Princess Margaret Hosp, Dept Med & Geriatr, Hong Kong, Peoples R China

[5] Queen Elizabeth Hosp, Dept Med, Hong Kong, Peoples R China

[6] Princess Margaret Hosp, Intens Care Unit, Hong Kong, Peoples R China

[7] Queen Elizabeth Hosp, Dept Pathol, Hong Kong, Peoples R China

[8] Queen Mary Hosp, Dept Med, Hong Kong, Peoples R China

来源：

CLINICAL INFECTIOUS DISEASES | 2020年 / 71卷 / 15期

关键词：

2019 novel coronavirus; saliva; diagnostics; viral load; transmission; COVID-19;

D O I：

10.1093/cid/ciaa149

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The 2019 novel coronavirus (2019-nCoV) was detected in the self-collected saliva of 91.7% (11/12) of patients. Serial saliva viral load monitoring generally showed a declining trend. Live virus was detected in saliva by viral culture. Saliva is a promising noninvasive specimen for diagnosis, monitoring, and infection control in patients with 2019-nCoV infection.

引用

页码：841 / 843

页数：3

共 12 条

[1]

[Anonymous], 2020, China Daily

[2]

Centre for Health Protection, 2020, SEV RESP DIS ASS NOV

[3] Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan [J].

Chan, Jasper Fuk-Woo ;

Kok, Kin-Hang ;

Zhu, Zheng ;

Chu, Hin ;

To, Kelvin Kai-Wang ;

Yuan, Shuofeng ;

Yuen, Kwok-Yung .

EMERGING MICROBES & INFECTIONS, 2020, 9 (01) :221-236

[4] A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster [J].

Chan, Jasper Fuk-Woo ;

Yuan, Shuofeng ;

Kok, Kin-Hang ;

To, Kelvin Kai-Wang ;

Chu, Hin ;

Yang, Jin ;

Xing, Fanfan ;

Liu, Jieling ;

Yip, Cyril Chik-Yan ;

Poon, Rosana Wing-Shan ;

Tsoi, Hoi-Wah ;

Lo, Simon Kam-Fai ;

Chan, Kwok-Hung ;

Poon, Vincent Kwok-Man ;

Chan, Wan-Mui ;

Ip, Jonathan Daniel ;

Cai, Jian-Piao ;

Cheng, Vincent Chi-Chung ;

Chen, Honglin ;

Hui, Christopher Kim-Ming ;

Yuen, Kwok-Yung .

LANCET, 2020, 395 (10223) :514-523

[5]

Huang C., 2020, LANCET, V395, P497, DOI [10.1016/s0140-6736(20)30183-5, DOI 10.1016/S0140-6736(20)30183-5]

[6] Epithelial Cells Lining Salivary Gland Ducts Are Early Target Cells of Severe Acute Respiratory Syndrome Coronavirus Infection in the Upper Respiratory Tracts of Rhesus Macaques [J].

Liu, Li ;

Wei, Qiang ;

Alvarez, Xavier ;

Wang, Haibo ;

Du, Yanhua ;

Zhu, Hua ;

Jiang, Hong ;

Zhou, Jingying ;

Lam, Pokman ;

Zhang, Linqi ;

Lackner, Andrew ;

Qin, Chuan ;

Chen, Zhiwei .

JOURNAL OF VIROLOGY, 2011, 85 (08) :4025-4030

[7] Coronavirus as a possible cause of severe acute respiratory syndrome [J].

Peiris, JSM ;

Lai, ST ;

Poon, LLM ;

Guan, Y ;

Yam, LYC ;

Lim, W ;

Nicholls, J ;

Yee, WKS ;

Yan, WW ;

Cheung, MT ;

Cheng, VCC ;

Chan, KH ;

Tsang, DNC ;

Yung, RWH ;

Ng, TK ;

Yuen, KY .

LANCET, 2003, 361 (9366) :1319-1325

[8] Respiratory virus infection among hospitalized adult patients with or without clinically apparent respiratory infection: a prospective cohort study [J].

To, K. K. W. ;

Chan, K. -H. ;

Ho, J. ;

Pang, P. K. P. ;

Ho, D. T. Y. ;

Chang, A. C. H. ;

Seng, C. W. ;

Yip, C. C. Y. ;

Cheng, V. C. C. ;

Hung, I. F. N. ;

Yuen, K. -Y. .

CLINICAL MICROBIOLOGY AND INFECTION, 2019, 25 (12) :1539-1545

[9] Saliva as a diagnostic specimen for testing respiratory virus by a point-of-care molecular assay: a diagnostic validity study [J].

To, K. K. W. ;

Yip, C. C. Y. ;

Lai, C. Y. W. ;

Wong, C. K. H. ;

Ho, D. T. Y. ;

Pang, P. K. P. ;

Ng, A. C. K. ;

Leung, K-H ;

Poon, R. W. S. ;

Chan, K-H ;

Cheng, V. C. C. ;

Hung, I. F. N. ;

Yuen, K-Y .

CLINICAL MICROBIOLOGY AND INFECTION, 2019, 25 (03) :372-378

[10] Additional molecular testing of saliva specimens improves the detection of respiratory viruses [J].

To, Kelvin Kw ;

Lu, Lu ;

Yip, Cyril C. Y. ;

Poon, Rosana W. S. ;

Fung, Ami M. Y. ;

Cheng, Andrew ;

Lui, Daniel H. K. ;

Ho, Deborah T. Y. ;

Hung, Ivan F. N. ;

Chan, Kwok-Hung ;

Yuen, Kwok-Yung .

EMERGING MICROBES & INFECTIONS, 2017, 6

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