Interactions in the (Pre)metastatic Niche Support Metastasis Formation

被引：116

作者：

Doglioni, Ginevra ^{[1
,2
,3
]}

Parik, Sweta ^{[1
,2
,3
]}

Fendt, Sarah-Maria ^{[1
,2
,3
]}

机构：

[1] VIB, VIB KU Leuven Ctr Canc Biol, Lab Cellular Metab & Metab Regulat, Leuven, Belgium

[2] Katholieke Univ Leuven, Lab Cellular Metab & Metab Regulat, Dept Oncol, Leuven, Belgium

[3] Leuven Canc Inst, Leuven, Belgium

来源：

FRONTIERS IN ONCOLOGY | 2019年 / 9卷

基金：

欧洲研究理事会;

关键词：

metastatic niche; premetastatic niche; tumor environment; immune cells; stromal cells; extracellular matrix; nutrient environment; tumor secreted factors; BREAST-CANCER CELLS; IMMUNE MICROENVIRONMENTS; TUMOR MICROENVIRONMENT; LYSYL OXIDASE; T-CELLS; METABOLISM; MACROPHAGES; COLONIZATION; PROGRESSION; FIBROBLASTS;

D O I：

10.3389/fonc.2019.00219

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Metastasis formation is the leading cause of death in cancer patients. Thus, understanding and targeting this process is an unmet need. Crucial steps during the establishment of metastases include the (pre)metastatic niche formation. This process relies on the interaction of the primary tumor with the environment of distant organs (premetastatic niche) and the interaction of cancer cells with their environment when arriving in a distant organ (metastatic niche). Here, we summarize the current knowledge on the interactions in the tumor environment that result in (pre)metastatic niche formation, specifically in the context of tumor secreted factors, extracellular matrix, immune as well as stromal cells, and nutrient availability. We further highlight strategies to disrupt these interactions as therapeutic interventions against metastases.

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