The nagging question of the function of N-acetylaspartylglutamate

被引：143

作者：

Coyle, JT ^{[1
]}

机构：

[1] HARVARD UNIV, SCH MED, DEPT PSYCHIAT, BELMONT, MA 02178 USA

来源：

NEUROBIOLOGY OF DISEASE | 1997年 / 4卷 / 3-4期

关键词：

D O I：

10.1006/nbdi.1997.0153

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

N-Acetylaspartylglutamate (NAAG) is a neuropeptide found in millimolar concentrations in brain that is localized to subpopulations of glutamatergic, cholinergic, GABAergic, and noradrenergic neuronal systems. NAAG is released upon depolarization by a Ca2+-dependent process and is an agonist at mGluR3 receptors and an antagonist at NMDA receptors. NAAG is catabolized to N-acetylaspartate and glutamate primarily by glutamate carboxypeptidase II, which is expressed on the extracellular surface of astrocytes. The levels of NAAG and the activity of carboxypeptidase II are altered in a regionally specific fashion in several neuropsychiatric disorders. (C) 1997 Academic Press.

引用

页码：231 / 238

页数：8

共 68 条

[41]

PUTTFARCKEN PS, 1993, J PHARMACOL EXP THER, V266, P796

[42] HISTAMINE-DEPENDENT FORMATION OF N-ACETYL-ASPARTYL PEPTIDES IN MOUSE BRAIN [J].

REICHELT, KL ;

KVAMME, E .

JOURNAL OF NEUROCHEMISTRY, 1973, 21 (04) :849-859

[43] QUISQUALATE SELECTIVELY INHIBITS A BRAIN PEPTIDASE WHICH CLEAVES N-ACETYL-L-ASPARTYL-L-GLUTAMATE INVITRO [J].

ROBINSON, MB ;

BLAKELY, RD ;

COYLE, JT .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1986, 130 (03) :345-347

[44]

ROBINSON MB, 1987, J BIOL CHEM, V262, P14498

[45] ABNORMAL EXCITATORY AMINO-ACID-METABOLISM IN AMYOTROPHIC-LATERAL-SCLEROSIS [J].

ROTHSTEIN, JD ;

TSAI, GC ;

KUNCL, RW ;

CLAWSON, L ;

CORNBLATH, DR ;

DRACHMAN, DB ;

PESTRONK, A ;

STAUCH, BL ;

COYLE, JT .

ANNALS OF NEUROLOGY, 1990, 28 (01) :18-25

[46] Presynaptic receptors and the control of glutamate exocytosis [J].

SanchezPrieto, J ;

Budd, DC ;

Herrero, I ;

Vazquez, E ;

Nicholls, DG .

TRENDS IN NEUROSCIENCES, 1996, 19 (06) :235-239

[47]

Santi M. R., 1995, Society for Neuroscience Abstracts, V21, P847

[48] Use-dependent increases in glutamate concentration activate presynaptic metabotropic glutamate receptors [J].

Scanziani, M ;

Salin, PA ;

Vogt, KE ;

Malenka, RC ;

Nicoll, RA .

NATURE, 1997, 385 (6617) :630-634

[49] LOW-CONCENTRATION N-ACETYLASPARTYLGLUTAMATE SUPPRESSES THE CLIMBING FIBER RESPONSE OF PURKINJE-CELLS IN GUINEA-PIG CEREBELLAR SLICES AND THE RESPONSES TO EXCITATORY AMINO-ACIDS OF XENOPUS-LAEVIS OOCYTES INJECTED WITH CEREBELLAR MESSENGER-RNA [J].

SEKIGUCHI, M ;

OKAMOTO, K ;

SAKAI, Y .

BRAIN RESEARCH, 1989, 482 (01) :87-96

[50]

SERVAL V, 1992, J PHARMACOL EXP THER, V260, P1093

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