Recommendations for cerebrospinal fluid Alzheimer's disease biomarkers in the diagnostic evaluation of mild cognitive impairment

被引：125

作者：

Herukka, Sanna-Kaisa ^{[1
,2
]}

Simonsen, Anja Hviid ^{[3
]}

Andreasen, Niels ^{[4
]}

Baldeiras, Ines ^{[5
]}

Bjerke, Maria ^{[6
]}

Blennow, Kaj ^{[7
]}

Engelborghs, Sebastiaan ^{[6
,8
,9
]}

Frisoni, Giovanni B. ^{[10
,11
,12
]}

Gabryelewicz, Tomasz ^{[13
]}

Galluzzi, Samantha ^{[12
]}

Handels, Ron ^{[14
]}

Kramberger, Milica G. ^{[15
]}

Kulczynska, Agnieszka ^{[16
]}

Luis Molinuevo, Jose ^{[17
,18
]}

Mroczko, Barbara ^{[16
,19
]}

Nordberg, Agneta ^{[20
]}

Oliveira, Catarina Resende ^{[5
]}

Otto, Markus ^{[21
]}

Rinne, Juha O. ^{[22
,23
]}

Rot, Uros ^{[15
]}

Saka, Esen ^{[24
]}

Soininen, Hilkka ^{[1
,2
]}

Struyfs, Hanne ^{[6
]}

Suardi, Silvia ^{[25
]}

Visser, Pieter Jelle ^{[26
,27
]}

Winblad, Bengt ^{[28
]}

Zetterberg, Henrik ^{[7
,29
]}

Waldemar, Gunhild ^{[3
]}

机构：

[1] Univ Eastern Finland, Dept Neurol, Kuopio, Finland

[2] Kuopio Univ Hosp, Kuopio, Finland

[3] Rigshosp, Copenhagen Univ Hosp, Danish Dementia Res Ctr, Copenhagen, Denmark

[4] Karolinska Univ Hosp, Dept Geriatr Med, Huddinge, Sweden

[5] Univ Coimbra, CHUC Coimbra Univ Hosp, CNC IBILI Ctr Neurosci & Cell Biol, Neurochem Lab,Fac Med,CNC, Coimbra, Portugal

[6] Univ Antwerp, Inst Born Bunge, Reference Ctr Biol Markers Dementia BIODEM, Antwerp, Belgium

[7] Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Molndal, Sweden

[8] Hosp Network Antwerp ZNA Middelheim & Hoge Beuken, Dept Neurol, Antwerp, Belgium

[9] Hosp Network Antwerp ZNA Middelheim & Hoge Beuken, Memory Clin, Antwerp, Belgium

[10] Univ Hosp, Geneva Neurosci Ctr, Geneva, Switzerland

[11] Univ Geneva, Geneva, Switzerland

[12] IRCCS Fatebenefratelli, Brescia, Italy

[13] Polish Acad Sci, Mossakowski Med Res Ctr, Dept Neurodegenerat Disorders, Warsaw, Poland

[14] Maastricht Univ, Sch Mental Hlth & Neurosci, Alzheimer Ctr Limburg, Maastricht, Netherlands

[15] Univ Med Ctr Ljubljana, Dept Neurol, Ctr Cognit Impairments, Ljubljana, Slovenia

[16] Med Univ Bialystok, Dept Neurodegenerat Diagnost, Bialystok, Poland

[17] IDIBAPS, Hosp Clin & Univ, Alzheimers Dis & Other Cognit Disorders Unit, Barcelona, Spain

[18] Fundacio Pasqual Maragall, Beta Brain Res Ctr, Barcelona, Spain

[19] Univ Hosp Bialystok, Dept Biochem Diagnost, Bialystok, Poland

[20] Karolinska Inst, Dept NVS, Ctr Alzheimer Res, Translat Alzheimer Neurobiol, Huddinge, Sweden

[21] Univ Ulm, Dept Neurol, Ulm, Germany

[22] Turku Univ Hosp, Turku PET Ctr, Turku, Finland

[23] Univ Turku, Turku, Finland

[24] Hacettepe Univ Hosp, Dept Neurol, Ankara, Turkey

[25] Neurol Inst C Besta, Neuropathol Lab, Milan, Italy

[26] Maastricht Univ, Sch Mental Hlth & Neurosci, Dept Psychiat & Neuropsychol, Maastricht, Netherlands

[27] Vrije Univ Amsterdam Med Ctr, Alzheimer Ctr, Dept Neurol, Amsterdam, Netherlands

[28] Karolinska Inst, Ctr Alzheimer Res, Div Neurogeriatr, Dept NVS, Huddinge, Sweden

[29] UCL Inst Neurol, Dept Mol Neurosci, London, England

来源：

ALZHEIMERS & DEMENTIA | 2017年 / 13卷 / 03期

基金：

芬兰科学院; 瑞典研究理事会;

关键词：

Alzheimer's disease; Biomarkers; CSF; Diagnostics; GRADE; Mild cognitive impairment; Recommendations; APOLIPOPROTEIN-E; ASSOCIATION WORKGROUPS; PHOSPHORYLATED-TAU; NATIONAL INSTITUTE; COST-EFFECTIVENESS; GRADING QUALITY; CSF; GUIDELINES; DEMENTIA; METAANALYSIS;

D O I：

10.1016/j.jalz.2016.09.009

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

This article presents recommendations, based on the Grading of Recommendations, Assessment, Development, and Evaluation method, for the clinical application of cerebrospinal fluid (CSF) amyloid-beta(1-42), tau, and phosphorylated tau in the diagnostic evaluation of patients with mild cognitive impairment (MCI). The recommendations were developed by a multidisciplinary working group and based on the available evidence and consensus from focused group discussions for 1) prediction of clinical progression to Alzheimer's disease (AD) dementia, 2) cost-effectiveness, 3)interpretation of results, and 4) patient counseling. The working group recommended using CSF AD biomarkers in the diagnostic workup of MCI patients, after prebiomarker counseling, as an add-on to clinical evaluation to predict functional decline or conversion to AD dementia and to guide disease management. Because of insufficient evidence, it was uncertain whether CSF AD biomarkers outperform imaging biomarkers. Furthermore, the working group provided recommendations for interpretation of ambiguous CSF biomarker results and for pre-and post-biomarker counseling. (C) 2016 The Authors. Published by Elsevier Inc. on behalf of the Alzheimer's Association.

引用

页码：285 / 295

页数：11

共 51 条

[1]

The diagnosis of mild cognitive impairment due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease [J].

Albert, Marilyn S. ;

DeKosky, Steven T. ;

Dickson, Dennis ;

Dubois, Bruno ;

Feldman, Howard H. ;

Fox, Nick C. ;

Gamst, Anthony ;

Holtzman, David M. ;

Jagust, William J. ;

Petersen, Ronald C. ;

Snyder, Peter J. ;

Carrillo, Maria C. ;

Thies, Bill ;

Phelps, Creighton H. .

ALZHEIMERS & DEMENTIA, 2011, 7 (03) :270-279

[2]

Mild cognitive impairment: coping with an uncertain label [J].

Banningh, Liesbeth Joosten-Weyn ;

Vernooij-Dassen, Myrra ;

Rikkert, Marcel Olde ;

Teunisse, Jan-Pieter .

INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, 2008, 23 (02) :148-154

[3]

Making sense of nonsense: experiences of mild cognitive impairment [J].

Beard, Renee L. ;

Neary, Tara M. .

SOCIOLOGY OF HEALTH & ILLNESS, 2013, 35 (01) :130-146

[4]

Alzheimer's disease [J].

Scheltens, Philip ;

De Strooper, Bart ;

Kivipelto, Miia ;

Holstege, Henne ;

Chetelat, Gael ;

Teunissen, Charlotte E. ;

Cummings, Jeffrey ;

van der Flier, Wiesje M. .

LANCET, 2021, 397 (10284) :1577-1590

[5]

The use of biomarkers for the etiologic diagnosis of MCI in Europe: An EADC survey [J].

Bocchetta, Martina ;

Galluzzi, Samantha ;

Kehoe, Patrick Gavin ;

Aguera, Eduardo ;

Bernabei, Roberto ;

Bullock, Roger ;

Ceccaldi, Mathieu ;

Dartigues, Jean-Francois ;

de Mendonca, Alexandre ;

Didic, Mira ;

Eriksdotter, Maria ;

Felician, Olivier ;

Froelich, Lutz ;

Gertz, Hermann-Josef ;

Hallikainen, Merja ;

Hasselbalch, Steen G. ;

Hausner, Lucrezia ;

Heuser, Isabell ;

Jessen, Frank ;

Jones, Roy W. ;

Kurz, Alexander ;

Lawlor, Brian ;

Lleo, Alberto ;

Martinez-Lage, Pablo ;

Mecocci, Patrizia ;

Mehrabian, Shima ;

Monsch, Andreas ;

Nobili, Flavio ;

Nordberg, Agneta ;

Rikkert, Marcel Olde ;

Orgogozo, Jean-Marc ;

Pasquier, Florence ;

Peters, Oliver ;

Salmon, Eric ;

Sanchez-Castellano, Carmen ;

Santana, Isabel ;

Sarazin, Marie ;

Traykov, Latchezar ;

Tsolaki, Magda ;

Visser, Pieter Jelle ;

Wallin, Asa K. ;

Wilcock, Gordon ;

Wilkinson, David ;

Wolf, Henrike ;

Yener, Goersev ;

Zekry, Dina ;

Frisoni, Giovanni B. .

ALZHEIMERS & DEMENTIA, 2015, 11 (02) :195-206

[6]

Bossuyt PMM, 2009, MED TESTS WHITE PAPE

[7]

Grading quality of evidence and strength of recommendations in clinical practice guidelines: Part 2 of 3. The GRADE approach to grading quality of evidence about diagnostic tests and strategies [J].

Brozek, J. L. ;

Akl, E. A. ;

Jaeschke, R. ;

Lang, D. M. ;

Bossuyt, P. ;

Glasziou, P. ;

Helfand, M. ;

Ueffing, E. ;

Alonso-Coello, P. ;

Meerpohl, J. ;

Phillips, B. ;

Horvath, A. R. ;

Bousquet, J. ;

Guyatt, G. H. ;

Schuenemann, H. J. .

ALLERGY, 2009, 64 (08) :1109-1116

[8]

Treatment for mild cognitive impairment: systematic review [J].

Cooper, Claudia ;

Li, Ryan ;

Lyketsos, Constantine ;

Livingston, Gill .

BRITISH JOURNAL OF PSYCHIATRY, 2013, 203 (04) :255-264

[9]

Do CSF total tau, phosphorylated tau, and β-amyloid 42 help to predict progression of mild cognitive impairment to Alzheimer's disease?: A systematic review and meta-analysis of the literature [J].

Diniz, Breno S. O. ;

Pinto, Jony A., Jr. ;

Forlenza, Orestes Vicente .

WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY, 2008, 9 (03) :172-182

[10]

Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria [J].

Dubois, Bruno ;

Feldman, Howard H. ;

Jacova, Claudia ;

Hampel, Harald ;

Molinuevo, Jose Luis ;

Blennow, Kaj ;

Dekosky, Steven T. ;

Gauthier, Serge ;

Selkoe, Dennis ;

Bateman, Randall ;

Cappa, Stefano ;

Crutch, Sebastian ;

Engelborghs, Sebastiaan ;

Frisoni, Giovanni B. ;

Fox, Nick C. ;

Galasko, Douglas ;

Habert, Marie-Odile ;

Jicha, Gregory A. ;

Nordberg, Agneta ;

Pasquier, Florence ;

Rabinovici, Gil ;

Robert, Philippe ;

Rowe, Christopher ;

Salloway, Stephen ;

Sarazin, Marie ;

Epelbaum, Stephane ;

de Souza, Leonardo C. ;

Vellas, Bruno ;

Visser, Pieter J. ;

Schneider, Lon ;

Stern, Yaakov ;

Scheltens, Philip ;

Cummings, Jeffrey L. .

LANCET NEUROLOGY, 2014, 13 (06) :614-629

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