Distribution of mapping points of 20 amino acids in the tetrahedral space

被引:1
作者
Zhang, R
机构
[1] Dept. of Epidemiol. and Biostatist., Tianjin Cancer Hosp. and Institute, Tianjin
[2] Dept. of Epidemiol. and Biostatist., Tianjin Cancer Hosp. and Institute
关键词
amino acids; mapping point; hydrophobicity; hydrophilicity; separating plane; Fisher's algorithm;
D O I
10.1007/BF01386479
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Based on the genetic codes and a simple theorem for the geometrical property of the regular tetrahedron, each amino acid is mapped onto a unique point in a 3-dimensional tetrahedral space. The distribution of the 20 mapping points for 20 amino acids is studied in detail. It is found that the mapping points for the hydrophobic and hydrophilic amino acids are distributed at distinct regions in the 3-dimensional space. A plane separating the two kinds of points satisfactorily based on the Fisher's algorithm has been calculated. It is shown that the codons coding for the hydrophobic amino acids are constituted dominantly by the bases of keto group, i.e., G and T. While the codons coding for the hydrophilic amino acids are constituted dominantly by the bases of amino group, i.e., A and C. The biological implication of the mapping points and the separating plane has been discussed in some details.
引用
收藏
页码:167 / 177
页数:11
相关论文
共 6 条
[1]  
Anderson T., 1984, INTRO MULTIVARIATE S
[2]   3-DIMENSIONAL STRUCTURE OF MEMBRANE AND SURFACE-PROTEINS [J].
EISENBERG, D .
ANNUAL REVIEW OF BIOCHEMISTRY, 1984, 53 :595-623
[3]   A TETRAHEDRAL REPRESENTATION OF POLY-CODON SEQUENCES AND A POSSIBLE ORIGIN OF CODON DEGENERACY [J].
TRAINOR, LEH ;
ROWE, GW ;
SZABO, VL .
JOURNAL OF THEORETICAL BIOLOGY, 1984, 108 (03) :459-468
[4]   ANALYSIS OF DISTRIBUTION OF BASES IN THE CODING SEQUENCES BY A DIAGRAMMATIC TECHNIQUE [J].
ZHANG, CT ;
ZHANG, R .
NUCLEIC ACIDS RESEARCH, 1991, 19 (22) :6313-6317
[5]   DIAGRAMMATIC REPRESENTATION OF THE DISTRIBUTION OF DNA BASES AND ITS APPLICATIONS [J].
ZHANG, CT ;
ZHANG, R .
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 1991, 13 (01) :45-49
[6]   Z-CURVES, AN INTUTIVE TOOL FOR VISUALIZING AND ANALYZING THE DNA-SEQUENCES [J].
ZHANG, R ;
ZHANG, CT .
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 1994, 11 (04) :767-782