Projection structure of a gap junction membrane channel at 7 angstrom resolution

被引：100

作者：

Unger, VM

Kumar, NM

Gilula, NB

Yeager, M

机构：

[1] SCRIPPS RES INST, DEPT CELL BIOL, LA JOLLA, CA 92037 USA

[2] SCRIPPS CLIN, DIV CARDIOVASC DIS, LA JOLLA, CA 92037 USA

来源：

NATURE STRUCTURAL BIOLOGY | 1997年 / 4卷 / 01期

关键词：

D O I：

10.1038/nsb0197-39

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Electron cryo-microscopy and image analysis of frozen-hydrated, two-dimensional crystals of gap junction membrane channels formed by recombinant alpha(1) connexin (Cx43) reveal a ring of transmembrane alpha-helices that lines the aqueous pore and a second ring of alpha-helices in close contact with the membrane lipids.

引用

收藏

页码：39 / 43

页数：5

相关论文

共 43 条

[1] 3-DIMENSIONAL STRUCTURE DETERMINATION BY ELECTRON-MICROSCOPY OF TWO-DIMENSIONAL CRYSTALS [J].

AMOS, LA ;

HENDERSON, R ;

UNWIN, PNT .

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, 1983, 39 (03) :183-231

[2] GAP JUNCTION STRUCTURES .4. ASYMMETRIC FEATURES REVEALED BY LOW-IRRADIATION MICROSCOPY [J].

BAKER, TS ;

CASPAR, DLD ;

HOLLINGSHEAD, CJ ;

GOODENOUGH, DA .

JOURNAL OF CELL BIOLOGY, 1983, 96 (01) :204-216

[3] CONNEXIN FAMILY OF GAP JUNCTION PROTEINS [J].

BEYER, EC ;

PAUL, DL ;

GOODENOUGH, DA .

JOURNAL OF MEMBRANE BIOLOGY, 1990, 116 (03) :187-194

[4] JUNCTIONS BETWEEN INTIMATELY APPOSED CELL MEMBRANES IN VERTEBRATE BRAIN [J].

BRIGHTMA.MW ;

REESE, TS .

JOURNAL OF CELL BIOLOGY, 1969, 40 (03) :648-+

[5] MUTATIONS OF THE CONNEXIN43 GAP-JUNCTION GENE IN PATIENTS WITH HEART MALFORMATIONS AND DEFECTS OF LATERALITY [J].

BRITZCUNNINGHAM, SH ;

SHAH, MM ;

ZUPPAN, CW ;

FLETCHER, WH .

NEW ENGLAND JOURNAL OF MEDICINE, 1995, 332 (20) :1323-1329

[6]

CASCIO M, 1990, J BIOL CHEM, V265, P2358

[7] GLIA-NEURON INTERCELLULAR CALCIUM SIGNALING [J].

CHARLES, AC .

DEVELOPMENTAL NEUROSCIENCE, 1994, 16 (3-4) :196-206

[8] HUMAN GROWTH-HORMONE AND EXTRACELLULAR DOMAIN OF ITS RECEPTOR - CRYSTAL-STRUCTURE OF THE COMPLEX [J].

DEVOS, AM ;

ULTSCH, M ;

KOSSIAKOFF, AA .

SCIENCE, 1992, 255 (5042) :306-312

[9] VARIATIONS IN TIGHT AND GAP JUNCTIONS IN MAMMALIAN TISSUES [J].

FRIEND, DS ;

GILULA, NB .

JOURNAL OF CELL BIOLOGY, 1972, 53 (03) :758-+

[10] ORGANIZATION OF CONNEXONS IN ISOLATED RAT-LIVER GAP-JUNCTIONS [J].

GOGOL, E ;

UNWIN, N .

BIOPHYSICAL JOURNAL, 1988, 54 (01) :105-112

← 1 2 3 4 5 →