Clinical Application of Bone Marrow Mesenchymal Stem/Stromal Cells to Repair Skeletal Tissue

被引：291

作者：

Arthur, Agnieszka ^{[1
,2
]}

Gronthos, Stan ^{[1
,2
]}

机构：

[1] Univ Adelaide, Adelaide Med Sch, Fac Hlth & Med Sci, Mesenchymal Stem Cell Lab, Adelaide, SA 5001, Australia

[2] South Australian Hlth & Med Res Inst, Precis Med Theme, Adelaide, SA 5001, Australia

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2020年 / 21卷 / 24期

基金：

英国医学研究理事会;

关键词：

bone marrow mesenchymal stem cells; bone marrow microenvironment; skeletal tissue regeneration; tissue engineering; scaffolds; biomaterials; ENDOTHELIAL PROGENITOR CELLS; PARATHYROID-HORMONE; 1-34; STEM-CELLS; OSTEOGENESIS IMPERFECTA; STROMAL CELLS; IN-VITRO; MORPHOGENETIC PROTEIN-2; SUSTAINED-RELEASE; MONONUCLEAR-CELLS; LOCAL INJECTION;

D O I：

10.3390/ijms21249759

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

There has been an escalation in reports over the last decade examining the efficacy of bone marrow derived mesenchymal stem/stromal cells (BMSC) in bone tissue engineering and regenerative medicine-based applications. The multipotent differentiation potential, myelosupportive capacity, anti-inflammatory and immune-modulatory properties of BMSC underpins their versatile nature as therapeutic agents. This review addresses the current limitations and challenges of exogenous autologous and allogeneic BMSC based regenerative skeletal therapies in combination with bioactive molecules, cellular derivatives, genetic manipulation, biocompatible hydrogels, solid and composite scaffolds. The review highlights the current approaches and recent developments in utilizing endogenous BMSC activation or exogenous BMSC for the repair of long bone and vertebrae fractures due to osteoporosis or trauma. Current advances employing BMSC based therapies for bone regeneration of craniofacial defects is also discussed. Moreover, this review discusses the latest developments utilizing BMSC therapies in the preclinical and clinical settings, including the treatment of bone related diseases such as Osteogenesis Imperfecta.

引用

页码：1 / 27

页数：28

共 191 条

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