Integrated actions of progesterone receptor and cell cycle machinery regulate breast cancer cell proliferation

被引：24

作者：

Dressing, Gwen E. ^{[1
]}

Lange, Carol A. ^{[1
]}

机构：

[1] Univ Minnesota, Mason Canc Ctr, Dept Med, Div Hematol Oncol & Transplantat, Minneapolis, MN 55455 USA

来源：

STEROIDS | 2009年 / 74卷 / 07期

关键词：

Progesterone receptor; Cell cycle; Cyclin D; p21; p27; Cyclin-dependent kinase 2; STEROID-HORMONE RECEPTORS; ACTIVATED PROTEIN-KINASE; ANDROGEN RECEPTOR; GROWTH-FACTOR; ESTROGEN-RECEPTOR; TRANSCRIPTIONAL ACTIVITY; GENE-EXPRESSION; CO-REPRESSOR; CROSS-TALK; B-ISOFORM;

D O I：

10.1016/j.steroids.2008.12.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Multiple laboratories have investigated progesterone receptor (PR) involvement in breast cancer cell cycle progression. There is now a growing body of evidence demonstrating complex interactions between PR and cell cycle regulatory proteins. Here we review the current literature linking PR to cell cycle control and discuss gaps in the current knowledge. A more complete understanding of the relationships between PR and cell cycle regulatory molecules may reveal additional avenues for prevention and treatment of steroid receptor positive breast cancers. (C) 2008 Elsevier Inc. All rights reserved.

引用

收藏

页码：573 / 576

页数：4

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