Physico-chemical characterization and synthesis of neuronally active α-conotoxins

被引：27

作者：

Loughnan, ML ^{[1
]}

Alewood, PF ^{[1
]}

机构：

[1] Univ Queensland, Inst Mol Sci, Brisbane, Qld 4072, Australia

来源：

EUROPEAN JOURNAL OF BIOCHEMISTRY | 2004年 / 271卷 / 12期

关键词：

alpha-conotoxins; Conus; peptide synthesis; post-translational; modifications sulfotyrosine;

D O I：

10.1111/j.1432-1033.2004.04146.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The high speciFIcity of alpha-conotoxins for different neuronal nicotinic acetylcholine receptors makes them important probes for dissecting receptor subtype selectivity. New sequences continue to expand the diversity and utility of the pool of available alpha-conotoxins. Their identification and characterization depend on a suite of techniques with increasing emphasis on mass spectrometry and microscale chromatography, which have benefited from recent advances in resolution and capability. Rigorous physicochemical analysis together with synthetic peptide chemistry is a prerequisite for detailed conformational analysis and to provide sufficient quantities of alpha-conotoxins for activity assessment and structure-activity relationship studies.

引用

页码：2294 / 2304

页数：11

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