Minimal variation in T-20 binding domain of different HIV-1 subtypes from antiretroviral-naive and -experienced patients

被引：51

作者：

Xu, L ^{[1
]}

Hué, S ^{[1
]}

Taylor, S ^{[1
]}

Ratcliffe, D ^{[1
]}

Workman, JA ^{[1
]}

Jackson, S ^{[1
]}

Cane, PA ^{[1
]}

Pillay, D ^{[1
]}

机构：

[1] Univ Birmingham, Sch Med, Div Immun & Infect, PHLS Antiviral Susceptibil Reference Unit, Birmingham B15 2TT, W Midlands, England

来源：

AIDS | 2002年 / 16卷 / 12期

关键词：

D O I：

10.1097/00002030-200208160-00016

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In-vitro differences in T-20 susceptibility among HIV-1 subtypes have been reported. We therefore studied the T-20 binding domain of a variety of virus subtypes from both antiretroviral-naive and -experienced patients. Minimal variation in the HR-1 region of gp41 was observed, especially within the region responsible for T-20 resistance. Any subtype differences in T-20 susceptibility do not appear to be related to HR-1 genetic variation.

引用

页码：1684 / 1686

页数：3

共 12 条

[1] Resistance-associated mutations in the human immunodeficiency virus type 1 subtype C protease gene from treated and untreated patients in the United Kingdom [J].

Cane, PA ;

de Ruiter, A ;

Rice, P ;

Wiselka, M ;

Fox, R ;

Pillay, D .

JOURNAL OF CLINICAL MICROBIOLOGY, 2001, 39 (07) :2652-2654

[2] Sensitivity of human immunodeficiency virus type 1 to fusion inhibitors targeted to the gp41 first heptad repeat involves distinct regions of gp41 and is consistently modulated by gp120 interactions with the coreceptor [J].

Derdeyn, CA ;

Decker, JM ;

Sfakianos, JN ;

Zhang, ZJ ;

O'Brien, WA ;

Ratner, L ;

Shaw, GM ;

Hunter, E .

JOURNAL OF VIROLOGY, 2001, 75 (18) :8605-8614

[3] Sensitivity of human immunodeficiency virus type 1 to the fusion inhibitor T-20 is modulated by coreceptor specificity defined by the V3 loop of gp120 [J].

Derdeyn, CA ;

Decker, JM ;

Sfakianos, JN ;

Wu, XY ;

O'Brien, WA ;

Ratner, L ;

Kappes, JC ;

Shaw, GM ;

Hunter, E .

JOURNAL OF VIROLOGY, 2000, 74 (18) :8358-8367

[4] Capture of an early fusion-active conformation of HIV-1 gp41 [J].

Furuta, RA ;

Wild, CT ;

Weng, YK ;

Weiss, CD .

NATURE STRUCTURAL BIOLOGY, 1998, 5 (04) :276-279

[5]

HAMMOND J, 1997, HUMAN RETROVIRUSES A

[6] Membrane-anchored peptide inhibits human immunodeficiency virus entry [J].

Hildinger, M ;

Dittmar, MT ;

Schult-Dietrich, P ;

Fehse, B ;

Schnierle, BS ;

Thaler, S ;

Stiegler, G ;

Welker, R ;

von Laer, D .

JOURNAL OF VIROLOGY, 2001, 75 (06) :3038-3042

[7] Potent suppression of HIV-1 replication in humans by T-20, a peptide inhibitor of gp41-mediated virus entry [J].

Kilby, JM ;

Hopkins, S ;

Venetta, TM ;

DiMassimo, B ;

Cloud, GA ;

Lee, JY ;

Alldredge, L ;

Hunter, E ;

Lambert, D ;

Bolognesi, D ;

Mathews, T ;

Johnson, MR ;

Nowak, MA ;

Shaw, GM ;

Saag, MS .

NATURE MEDICINE, 1998, 4 (11) :1302-1307

[8] Detection of drug resistance associated mutations in HIV primary infection within the UK [J].

Pillay, D ;

Cane, PA ;

Shirley, J ;

Porter, K .

AIDS, 2000, 14 (07) :906-908

[9] Determinants of human immunodeficiency virus type 1 resistance to gp41-derived inhibitory peptide [J].

Rimsky, LT ;

Shugars, DC ;

Matthews, TJ .

JOURNAL OF VIROLOGY, 1998, 72 (02) :986-993

[10] Human immunodeficiency virus reverse transcriptase and protease sequence database [J].

Shafer, RW ;

Jung, DR ;

Betts, BJ ;

Xi, YO ;

Gonzales, MJ .

NUCLEIC ACIDS RESEARCH, 2000, 28 (01) :346-348

← 1 2 →