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A member of the frizzled protein family mediating axis induction by Wnt-5A

被引：405
作者：
He, X
SaintJeannet, JP
Wang, YS
Nathans, J
Dawid, I
Varmus, H
机构：
[1] NCI,NIH,BETHESDA,MD 20892
[2] NICHHD,NIH,BETHESDA,MD 20892
[3] JOHNS HOPKINS UNIV,SCH MED,DEPT MOL BIOL & GENET,HOWARD HUGHES MED INST,BALTIMORE,MD 21205
来源：
SCIENCE | 1997年 / 275卷 / 5306期
关键词：
D O I：
10.1126/science.275.5306.1652
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
In Xenopus laevis embryos, the Wingless/Wnt-1 subclass of Wnt molecules induces axis duplication, whereas the Wnt-5A subclass does not. This difference could be explained by distinct signal transduction pathways or by a lack of one or more Wnt-5A receptors during axis formation. Wnt-5A induced axis duplication and an ectopic Spemann organizer in the presence of hFz5, a member of the Frizzled family of seven-transmembrane receptors. Wnt-5A/hFz5 signaling was antagonized by glycogen synthase kinase-3 and by the amino-terminal ectodomain of hFz5. These results identify hFz5 as a receptor for Wnt-5A.
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页码：1652 / 1654
页数：3
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