Purity control of carbamazepine by micellar electrokinetic chromatography

被引：11

作者：

Degenhardt, M ^{[1
]}

Watzig, H ^{[1
]}

机构：

[1] UNIV WURZBURG,DEPT PHARM & FOOD CHEM,D-97074 WURZBURG,GERMANY

来源：

JOURNAL OF CHROMATOGRAPHY A | 1997年 / 768卷 / 01期

关键词：

pharmaceutical analysis; carbamazepine; dihydrocarbamazepine;

D O I：

10.1016/S0021-9673(97)00073-3

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Carbamazepine is separated from 10,11-dihydrocarbamazepine and other impurities using a solution of sodium tetraborate decahydrate (12.5 mmol/l) and sodium dodecyl sulfate (50 mmol/l) in water-methanol (9:1, w/w; apparent pH 9.2). This method is optimised with regard to concentration of the organic modifier, temperature and voltage. The influence of the capillary type and the instrumentation has been studied in order to validate the robustness of this method.

引用

页码：113 / 123

页数：11

共 22 条

[1]

Altria K. D, 1996, CAPILLARY ELECTROPHO

[2] AN OVERVIEW OF METHOD VALIDATION AND SYSTEM SUITABILITY ASPECTS IN CAPILLARY ELECTROPHORESIS [J].

ALTRIA, KD ;

RUDD, DR .

CHROMATOGRAPHIA, 1995, 41 (5-6) :325-331

[3] DETERMINATION OF BENZODIAZEPINES BY MICELLAR ELECTROKINETIC CHROMATOGRAPHY [J].

BECHET, I ;

FILLET, M ;

HUBERT, P ;

CROMMEN, J .

ELECTROPHORESIS, 1994, 15 (10) :1316-1321

[4]

CLAESSENS HA, 1994, J HIGH RES CHROMATOG, V17, P325

[5]

CLAESSENS HA, 1993, RIVA GARDA, P145

[6] OPTIMIZATION OF SELECTIVITY IN CAPILLARY ELECTROPHORESIS WITH EMPHASIS ON MICELLAR ELECTROKINETIC CAPILLARY CHROMATOGRAPHY [J].

CORSTJENS, H ;

BILLIET, HAH ;

FRANK, J ;

LUYBEN, KCAM .

JOURNAL OF CHROMATOGRAPHY A, 1995, 715 (01) :1-11

[7]

ENGELHARDT H, 1993, J CHROMATOGR A, V652, P309

[8]

EVENSON MA, 1992, CLIN CHEM, V38, P1847

[9]

HIRAOKA A, 1994, SEIBUTSU SHIRYO BUNS, V17, P274

[10]

Kuhn R., 1993, capillary electrophoresis: principles and practice, DOI DOI 10.1007/978-3-642-78058-5

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