Randomized clinical trial of the efficacy of Bupropion combined with nicotine patch in the treatment of adolescent smokers

被引:91
作者
Killen, JD
Robinson, TN
Ammerman, S
Hayward, C
Rogers, J
Stone, C
Samuels, D
Levin, SK
Green, S
Schatzberg, AF
机构
[1] Stanford Univ, Sch Med, Stanford Ctr Res Dis Prevent, Dept Med, Stanford, CA 94305 USA
[2] Stanford Univ, Sch Med, Dept Pediat, Stanford, CA 94305 USA
[3] Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA
关键词
D O I
10.1037/0022-006X.72.4.729
中图分类号
B849 [应用心理学];
学科分类号
040203 ;
摘要
Adolescent smokers (N = 211) were randomized to 1 of 2 groups: (a) nicotine patch plus bupropion SR (sustained release; 150 mg per day) or (b) nicotine patch plus placebo. Group skills training sessions were conducted each week by research staff. Abstinence rates at Weeks 10 and 26 were as follows: (a) patch plus bupropion, 23% and 8%, (b) patch plus placebo, 28% and 7%. Despite the lack of a treatment effect, a large majority of adolescents in both treatment groups reduced their consumption to a few cigarettes per day or less and maintained this reduction over time. Similarly, an examination of survival curves revealed that by the end of treatment many had managed to avoid a return to daily smoking. These findings are encouraging and suggest new avenues for research. For example, treatments of the kind examined in this report, augmented by extended maintenance therapies, may yield higher long-term success rates.
引用
收藏
页码:729 / 735
页数:7
相关论文
共 16 条
[1]  
Allison PD., 2010, SURVIVAL ANAL USING
[2]   THE EFFECTIVENESS OF THE NICOTINE PATCH FOR SMOKING CESSATION - A METAANALYSIS [J].
FIORE, MC ;
SMITH, SS ;
JORENBY, DE ;
BAKER, TB .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1994, 271 (24) :1940-1947
[3]  
First S., 1995, BIOMETRICS RES DEP
[4]   Psychological intervention and antidepressant treatment in smoking cessation [J].
Hall, SM ;
Humfleet, GL ;
Reus, VI ;
Muñoz, RF ;
Hartz, DT ;
Maude-Griffin, R .
ARCHIVES OF GENERAL PSYCHIATRY, 2002, 59 (10) :930-936
[5]  
Hurt RD, 2000, ARCH PEDIAT ADOL MED, V154, P31
[6]   A comparison of sustained-release bupropion and placebo for smoking cessation [J].
Hurt, RD ;
Sachs, DPL ;
Glover, ED ;
Offord, KP ;
Johnston, JA ;
Dale, LC ;
Khayrallah, MA ;
Schroeder, DR ;
Glover, PN ;
Sullivan, CR ;
Croghan, IT ;
Sullivan, PM .
NEW ENGLAND JOURNAL OF MEDICINE, 1997, 337 (17) :1195-1202
[7]  
Johnston L.D., 2000, MONITORING FUTURE NA
[8]  
Jorenby DE, 1999, NEW ENGL J MED, V340, P685, DOI 10.1056/NEJM199903043400903
[9]   Craving is associated with smoking relapse: Findings from three prospective studies [J].
Killen, JD ;
Fortmann, SP .
EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY, 1997, 5 (02) :137-142
[10]  
Mermelstein Robin, 2002, Nicotine Tob Res, V4, P395, DOI 10.1080/1462220021000018470