The role of UBF in regulating the structure and dynamics of transcriptionally active rDNA chromatin

被引：109

作者：

Sanij, Elaine ^{[1
]}

Hannan, Ross D. ^{[1
,2
,3
]}

机构：

[1] Peter MacCallum Canc Ctr, Div Res, Melbourne, Vic, Australia

[2] Univ Melbourne, Dept Biochem & Mol Biol, Melbourne, Vic, Australia

[3] Monash Univ, Dept Biochem & Mol Biol, Melbourne, Vic 3004, Australia

来源：

EPIGENETICS | 2009年 / 4卷 / 06期

基金：

英国医学研究理事会;

关键词：

ribosomal genes; UBF; chromatin remodeling; methylation; RNA-POLYMERASE-I; UPSTREAM BINDING-FACTOR; RIBOSOMAL DNA-TRANSCRIPTION; GENE-TRANSCRIPTION; SACCHAROMYCES-CEREVISIAE; NEONATAL CARDIOMYOCYTES; TIF-IA; PHOSPHORYLATION; HYPERTROPHY; COMPLEX;

D O I：

10.4161/epi.4.6.9449

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Somatic cells have - 200 hundred copies of ribosomal RNA (rRNA) genes (rDNA) per haploid genome of which only a fraction are transcribed by RNA polymerase I (Pol I) at any given time. Thus regulation of rDNA transcription involves controlling both the number of active genes as well as the rate of transcription per gene. How and why a majority of rDNA are silenced is unclear but recent studies indicate that in addition to controlling rRNA synthesis, rDNA silencing plays an essential role in maintaining the genetic stability of rDNA repeats and influences cellular events such as aging and senescence. In this review we discuss the role of the cytoarchitectural transcription factor UBF in determining and maintaining the active (euchromatic) state of rDNA in mammals. In particular we discuss evidence to suggest that UBF dynamically regulates the active rRNA gene pool during differentiation and malignancy.

引用

页码：274 / 281

页数：8

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