α-Melanocyte stimulating hormone has beneficial effects on cerulein-induced acute pancreatitis

被引：16

作者：

Jahovic, N

Arbak, S

Tekeli, Ö

Alican, I ^{[1
]}

机构：

[1] Marmara Univ, Sch Med, Dept Physiol, TR-81326 Istanbul, Turkey

[2] Marmara Univ, Sch Med, Dept Histol & Embryol, TR-81326 Istanbul, Turkey

[3] Marmara Univ, Sch Med, Dept Biochem, TR-81326 Istanbul, Turkey

来源：

PEPTIDES | 2004年 / 25卷 / 01期

关键词：

pancreatitis; alpha-melanocyte stimulating hormone; neutrophils; rat;

D O I：

10.1016/j.peptides.2003.11.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We investigated the effect of alpha-melanocyte stimulating hormone (alpha-MSH) on cerulein induced acute pancreatitis in rats. alpha-MSH treatment (50 mug per rat, intraperitoneally) prior to cerulein reduced the plasma amylase level, pancreatic weight, pancreatic myeloperoxidase activity and the severity of the lesions microscopically. These data suggest that a-MSH has a protective effect on cerulein-induced acute pancreatitis and this effect could be attributed, at least in part, to decreased tissue leukocyte infiltration and thus, to decreased pro-inflammatory cytokine production and/or oxygen- and nitrogen-derived reactive metabolite release. (C) 2004 Elsevier Inc. All nights reserved.

引用

页码：129 / 132

页数：4

共 19 条

[11] Systemically administered α-melanocyte-stimulating peptides inhibit NF-κB activation in experimental brain inflammation [J].