Comparative Study of the Effects of a 1-Year Dietary Intervention of a Low-Carbohydrate Diet Versus a Low-Fat Diet on Weight and Glycemic Control in Type 2 Diabetes

被引:193
作者
Davis, Nichola J. [1 ,2 ]
Tomuta, Nora [1 ]
Schechter, Clyde [1 ]
Isasi, Carmen R. [1 ]
Segal-Isaacson, C. J. [1 ]
Stein, Daniel [1 ]
Zonszein, Joel [2 ]
Wylie-Rosett, Judith [1 ]
机构
[1] Yeshiva Univ Albert Einstein Coll Med, Bronx, NY 10461 USA
[2] N Bronx Healthcare Network, Bronx, NY USA
关键词
BLOOD-GLUCOSE; MELLITUS; OBESITY; INSULIN; ADULTS;
D O I
10.2337/dc08-2108
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVE - To compare the effects of a 1-year intervention with a low-carbohydrate and a low-fat diet on weight loss and glycemic control in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS - This study is a randomized clinical trial of 105 overweight adults with type 2 diabetes. Primary outcomes were weight and A1C. Secondary outcomes included blood pressure and lipids. Outcome measures were obtained at 3, 6, and 12 months. RESULTS - The greatest reduction in weight and A1C occurred Within the first 3 months. Weight loss occurred faster in the low-carbohydrate group than in the low-fat group (P = 0.005), but at 1 year a similar 3.4% weight reduction was seen in both dietary groups. There was no significant change in A1C in either group at I year. There was no change in blood pressure, but a greater increase in HDL was observed in the low-carbo hydrate group (P = 0.002). CONCLUSIONS - Among patients with type 2 diabetes, after I year a low-carbohydrate diet had effects on weight and A1C similar to those seen with a low-fat diet. There was no significant effect on blood pressure, but the low-carbohydrate diet produced a greater increase in HDL cholesterol.
引用
收藏
页码:1147 / 1152
页数:6
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