Partitioning of solvent effects and intrinsic interactions in biological recognition

被引：18

作者：

Kitova, EN ^{[1
]}

Bundle, DR ^{[1
]}

Klassen, JS ^{[1
]}

机构：

[1] Univ Alberta, Dept Chem, Edmonton, AB T6G 2G2, Canada

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 32期

关键词：

mass spectrometry; molecular recognition; oligosaccharides; proteins; solvent effects;

D O I：

10.1002/anie.200353051

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Divide and conquer: A novel approach was used to separate solvent effects from the intrinsic interactions involved in the association of biological complexes (see figure). The enthalpy of solvent reorganization for the formation of an intermolecular hydrogen bond in a biomolecular complex was determined by comparing the solution and gas-phase stabilities of structurally related complexes.

引用

页码：4183 / 4186

页数：4

共 24 条

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Bohm H.-J., 2003, PROTEIN LIGAND INTER

[2] MOLECULAR RECOGNITION OF A SALMONELLA TRISACCHARIDE EPITOPE BY MONOCLONAL-ANTIBODY SE155-4 [J].