Evidence for a Re-Evaluation of the Neurochemical and Anatomical Bases of Chemotherapy-Induced Vomiting

被引：86

作者：

Darmani, Nissar A. ^{[1
]}

Ray, Andrew P. ^{[1
]}

机构：

[1] Western Univ Hlth Sci, Dept Basic Med Sci, Coll Osteopath Med Pacific, Pomona, CA 91766 USA

来源：

CHEMICAL REVIEWS | 2009年 / 109卷 / 07期

关键词：

CISPLATIN-INDUCED EMESIS; DORSAL MOTOR NUCLEUS; NK1 RECEPTOR ANTAGONIST; CANNABINOID CB1 RECEPTOR; BLOOD-BRAIN-BARRIER; LOWER ESOPHAGEAL SPHINCTER; ENTERIC NERVOUS-SYSTEM; VAGAL AFFERENT NEURONS; C-FOS PROTEIN; ORAL NEUROKININ-1 ANTAGONIST;

D O I：

10.1021/cr900117p

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Evidence for a re-evaluation of the neurochemical and anatomical bases of chemotherapy-induced vomiting is discussed. Emetic signaling is initiated in the gastrointestinal tract in chemotherapy-induced vomiting and many other forms of vomiting. Cancer patients receiving chemotherapy experience not only emesis but also nausea, which is a continuous feeling of gastric discomfort, rather than the episodic discomfort of vomiting. However, salivation, chewing, and retching behaviors are usually considered part of the prodromal phase run by the motor program in the emetic circuitry, and may not be related to nauseous circuits. A 5-HT3 antagonist and dexamethasone, culminates in efficacy against nausea reported in chemotherapy. More comprehensive multineurotransmitter turnover measurements in patients could be made, which would lead to utilization of more broad-spectrum antiemetic regimens for the prevention of chemotherapy-induced vomiting in the clinic.

引用

页码：3158 / 3199

页数：42

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