Role of retinoid signaling in the regulation of spermatogenesis

被引:89
作者
Chung, SSW
Wolgemuth, DJ
机构
[1] Columbia Univ Coll Phys & Surg, Dept Genet & Dev, New York, NY 10032 USA
[2] Columbia Univ Coll Phys & Surg, Dept Obstet & Gynecol, New York, NY 10032 USA
[3] Columbia Univ Coll Phys & Surg, Ctr Reprod Sci, New York, NY 10032 USA
[4] Columbia Univ Coll Phys & Surg, Herbert Irving Comprehens Canc Ctr, New York, NY 10032 USA
关键词
D O I
10.1159/000078189
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
While the need for vitamin A for the normal progression of male germ cell differentiation has been known for many years, the molecular mechanisms underlying this requirement are poorly understood. This review will explore the aspects of the effects on spermatogenesis of dietary deprivation of vitamin A, in particular as to how they compare to the male sterility that results from the genetic ablation of function of the retinoid receptor RARalpha. The effects of other genes involved with retinoid synthesis, transport, and degradation are also considered. The possible cellular mechanisms that may be affected by the lack of retinoid signaling are discussed, in particular, cell cycle regulation and cell-cell interaction, both of which are critical for normal spermatogenesis. Copyright (C) 2004 S. Karger AG, Basel.
引用
收藏
页码:189 / 202
页数:14
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