Reaction of indole-2,3-dicarboxylic anhydride with (3-bromo-4-pyridyl)triisopropoxytitanium: Synthesis of ellipticine

被引：33

作者：

Miki, Y

Tada, Y

Yanase, N

Hachiken, H

Matsushita, K

机构：

[1] Faculty of Pharmaceutical Sciences, Kinki University, Higashi-Osaka 577

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 43期

关键词：

D O I：

10.1016/0040-4039(96)01768-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-Benzylindole-2,3-dicarboxylic anhydride (1) was reacted with (3-bromo-4-pyridyl)triisopropoxytitanium to give 2-(3-bromoisonicotinoyl)indole-3-carboxylic acid (2) as the sole product in high yield, which could be converted to ellipticine in six steps. Copyright (C) 1996 Elsevier Science Ltd

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页码：7753 / 7754

页数：2

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