Comparison of effects of carvedilol versus metoprolol on cytokine levels in patients with idiopathic dilated cardiomyopathy

被引：28

作者：

Ohtsuka, T ^{[1
]}

Hamada, M ^{[1
]}

Saeki, H ^{[1
]}

Ogimoto, A ^{[1
]}

Hiasa, G ^{[1
]}

Hara, Y ^{[1
]}

Shigematsu, Y ^{[1
]}

Hiwada, K ^{[1
]}

机构：

[1] Ehime Univ, Sch Med, Dept Internal Med 2, Shigenobu, Ehime 7910295, Japan

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2002年 / 89卷 / 08期

关键词：

D O I：

10.1016/S0002-9149(02)02258-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This study compared the effects of carvedilol versus metoprolol on cytokine levels and left ventricular (LV) performance in patients with idiopathic dilated cardiomyopathy (IDC). Carvedilol reduced circulating interleukin-6 more than metoprolol in patients with IDC and the reduction of interleukin-6 with carvedilol appears to be closely related to the improvement of LV systolic function in IDC.

引用

页码：996 / +

页数：6

共 19 条

[1] Cytokine network in congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy [J].

Aukrust, P ;

Ueland, T ;

Lien, E ;

Bendtzen, K ;

Müller, F ;

Andreassen, AK ;

Nordoy, I ;

Aass, H ;

Espevik, T ;

Simonsen, S ;

Froland, SS ;

Gullestad, L .

AMERICAN JOURNAL OF CARDIOLOGY, 1999, 83 (03) :376-382

[2]

BRAILLY H, 1994, CLIN CHEM, V40, P116

[3] Long-term effects of carvedilol in idiopathic dilated cardiomyopathy with persistent left ventricular dysfunction despite chronic metoprolol [J].

Di Lenarda, A ;

Sabbadini, G ;

Salvatore, L ;

Sinagra, G ;

Mestroni, L ;

Pinamonti, B ;

Gregori, D ;

Ciani, F ;

Muzzi, A ;

Klugmann, S ;

Camerini, F .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1999, 33 (07) :1926-1934

[4] INTERLEUKIN-6 (IL-6) AS A MEDIATOR OF STUNNED MYOCARDIUM [J].

FINKEL, MS ;

HOFFMAN, RA ;

SHEN, L ;

ODDIS, CV ;

SIMMONS, RL ;

HATTLER, BG .

AMERICAN JOURNAL OF CARDIOLOGY, 1993, 71 (13) :1231-1232

[5] NEGATIVE INOTROPIC EFFECTS OF CYTOKINES ON THE HEART MEDIATED BY NITRIC-OXIDE [J].

FINKEL, MS ;

ODDIS, CV ;

JACOB, TD ;

WATKINS, SC ;

HATTLER, BG ;

SIMMONS, RL .

SCIENCE, 1992, 257 (5068) :387-389

[6] Effect of high- versus low-dose angiotensin converting enzyme inhibition on cytokine levels in chronic heart failure [J].

Gullestad, L ;

Aukrust, P ;

Ueland, T ;

Espevik, T ;

Yee, G ;

Vagelos, R ;

Froland, SS ;

Fowler, M .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1999, 34 (07) :2061-2067

[7] Increased plasma levels of adrenomedullin in patients with hypertrophic cardiomyopathy: its relation to endothelin-I, natriuretic peptides and noradrenaline [J].

Hamada, M ;

Shigematsu, Y ;

Kawakami, H ;

Minamino, N ;

Kangawa, K ;

Matsuo, H ;

Hiwada, K .

CLINICAL SCIENCE, 1998, 94 (01) :21-28

[8] Effect of beta-blocker on left ventricular function and natriuretic peptides in patients with chronic heart failure treated with angiotensin-converting enzyme inhibitor [J].

Hara, Y ;

Hamada, M ;

Shigematsu, Y ;

Suzuki, M ;

Kodama, K ;

Kuwahara, T ;

Hashida, H ;

Ikeda, S ;

Ohtsuka, T ;

Hiasa, G ;

Hiwada, K .

JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION, 2000, 64 (05) :365-369

[9] ELEVATED CIRCULATING LEVELS OF TUMOR-NECROSIS-FACTOR IN SEVERE CHRONIC HEART-FAILURE [J].

LEVINE, B ;

KALMAN, J ;

MAYER, L ;

FILLIT, HM ;

PACKER, M .

NEW ENGLAND JOURNAL OF MEDICINE, 1990, 323 (04) :236-241

[10]

Metra M, 2000, CIRCULATION, V102, P546

← 1 2 →