Multicomponent Biginelli's synthesis of 3,4-dihydropyrimidin-2(1H)-ones promoted by SnCl2•2H2O

被引：139

作者：

Russowsky, D ^{[1
]}

Lopes, FA

da Silva, VSS

Canto, KFS

D'Oca, MGM

Godoi, MN

机构：

[1] Univ Fed Rio Grande do Sul, Inst Quim, BR-91501970 Porto Alegre, RS, Brazil

[2] Fdn Univ Rio Grande, Dept Quim, BR-96201900 Rio Grande, RS, Brazil

来源：

JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY | 2004年 / 15卷 / 02期

关键词：

Biginelli reaction; multicomponent reaction; dihydropyrimidinones; tin(II) chloride hydrate; Lewis acid;

D O I：

10.1590/S0103-50532004000200002

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The ability of SnCl2.2H(2)O as catalyst to promote the Biginelli three-component condensation reaction from a diversity of aromatic aldehydes, ethyl acetoacetate and urea or thiourea is described. The reaction was carried out in acetonitrile or ethanol as solvents in neutral media and represents an improvement of the classical Biginelli protocol and an advantage in comparison with FeCl3.6H(2)O, NiCl2.6H(2)O and CoCl2.6H(2)O which were used with HCl as co-catalyst. The synthesis of 3,4-dihydropyrimidinones was achieved in good to excellent yields.

引用

页码：165 / 169

页数：5

共 55 条

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