Unfolded proteins and protein folding studied by NMR

被引：507

作者：

Dyson, HJ ^{[1
]}

Wright, PE ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Mol Biol MB2, La Jolla, CA 92037 USA

来源：

CHEMICAL REVIEWS | 2004年 / 104卷 / 08期

关键词：

D O I：

10.1021/cr030403s

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

NMR remains one of the few comprehensive sources for information on unstructured and partly structured proteins and on the protein folding process. A review is given of NMR methods that are particularly applicable to the study of unfolded and partly folded proteins, and the types of information that can be obtained. Examples of protein systems in which NMR has been instrumental in the elucidation of folding pathways and mechanisms are considered. Furthermore, a few examples are provided of NMR studies of functional unfolded proteins.

引用

页码：3607 / 3622

页数：16

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