Telomerase activation and cancer

被引:37
作者
Klingelhutz, AJ
机构
[1] Fred Hutchinson Cancer Res. Center, Seattle, WA 98104
来源
JOURNAL OF MOLECULAR MEDICINE-JMM | 1997年 / 75卷 / 01期
关键词
telomere; telomerase; human papillomavirus; cancer;
D O I
10.1007/s001090050085
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Normal human cells have a limited life span in culture. It is generally believed that progression of cells to malignancy requires an overriding of this natural program of cellular senescence. An understanding of the genes controlling senescence will likely be valuable in determining the underlying mechanisms of abnormal cell growth and carcinogenesis. The hypothesis that telomeres play an integral role in cell senescence and immortalization has recently received much attention. This review discusses some of the current literature pertaining to how telomeres and activation of telomerase, a ribonucleoprotein that synthesizes telomere repeats, are believed to be involved in the process of immortalization. It also discusses how a further understanding of the telomerase enzyme may lead to better diagnostic and treatment strategies for a variety of cancer types.
引用
收藏
页码:45 / 49
页数:5
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