The enzymatic resolution of an α-fluoroamide by an acylase

被引：8

作者：

Banks, JW

O'Hagan, D

机构：

[1] Univ Durham, Dept Chem, Sci Labs, Durham DH1 3LE, England

[2] Searle, Dept Chem Technol, Morpeth NE61 3YA, England

来源：

JOURNAL OF FLUORINE CHEMISTRY | 2000年 / 102卷 / 1-2期

关键词：

F-19-NMR; acylase; Aspergillus melleus; alpha-fluoroamide; enzyme resolution;

D O I：

10.1016/S0022-1139(99)00284-5

中图分类号：

O61 [无机化学];

学科分类号：

070301 [无机化学]; 081704 [应用化学];

摘要：

The acylase from Aspergillus melleus was able to hydrolyse the amide bond of (S)-phenylalanine-N-2-(R,S)-fluoropropionamide and discriminate the diastereoisomers such that the (S,S)-diastereoisomer was hydrolysed by an order of magnitude faster than the (S,R)diasteroisomer. The origin of the kinetic discrimination is attributed to both binding and kinetic effects. (C) 2000 Elsevier Science S.A. All rights reserved.

引用

收藏

页码：235 / 238

页数：4

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