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Surface NK receptors and their ligands on tumor cells

被引：230
作者：
Moretta, Lorenzo
Bottino, Christina
Pende, Daniela
Castriconi, Roberta
Mingari, Maria Cristina
Moretta, Alessandro
机构：
[1] Ist Giannina Gaslini, I-16148 Genoa, Italy
[2] Univ Genoa, Dipartimento Med Sperimentale, I-16132 Genoa, Italy
[3] Univ Genoa, Ctr Eccellenza Ric Biomed, Genoa, Italy
[4] Ist Nazl Ric Canc, I-16132 Genoa, Italy
[5] Univ Genoa, Dipartimento Oncol Biol & Genet, I-16132 Genoa, Italy
来源：
SEMINARS IN IMMUNOLOGY | 2006年 / 18卷 / 03期
关键词：
natural killer cells; cytolytic T lymphocytes; killer Ig-like receptors; HLA-class I molecules; inhibitory receptors; activating receptors; KIR repertoire;
D O I：
10.1016/j.smim.2006.03.002
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The identification of MHC-class I-specific inhibitory receptors in humans and mice provided a first explanation of why NK cells can kill target cells that have lost or underexpress MHC-class I molecules but spare normal cells. However, the molecular basis of NK-mediated recognition and tumor cell killing revealed a higher degree of complexity. Thus, under pathological conditions, NK cells may express insufficient amounts of triggering receptors and target cells may or may not express ligands for such receptors. Here we briefly illustrate the main NK receptors and their cellular ligands and we delineate the major receptor/ligands interactions leading to NK cell activation and tumor cell lysis. (C) 2006 Elsevier Ltd. All rights reserved.
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收藏
页码：151 / 158
页数：8
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