Synthesis of the racemic tetracyclic core of CP-225,917: use of a strain-assisted Cope rearrangement

被引：16

作者：

Clive, DLJ ^{[1
]}

Ou, L ^{[1
]}

机构：

[1] Univ Alberta, Dept Chem, Edmonton, AB T6G 2G2, Canada

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 25期

基金：

加拿大自然科学与工程研究理事会;

关键词：

Cope rearrangement; strain; anhydride; furan; sodium chlorite; ruthenium dioxide; bridgehead olefin;

D O I：

10.1016/S0040-4039(02)00741-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Norbornene was converted via diketone 23 into the strained lactone 27; this was rearranged thermally to lactone 28, from which point the complete oxygenated core of CP-225,917 is accessible by deprotection and oxidation steps, including a new method for converting a furan system into a hydroxy butenolide. (C) 2002 Published by Elsevier Science Ltd.

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收藏

页码：4559 / 4563

页数：5

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