Functional genomic analysis of amniotic fluid cell-free mRNA suggests that oxidative stress is significant in Down syndrome fetuses
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Slonim, Donna K.
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Tufts Univ, Sch Med, Dept Pathol, Boston, MA 02111 USA
Tufts Univ, Dept Comp Sci, Medford, MA 02155 USAFloating Hosp Children, Tufts Med Ctr, Dept Pediat, Div Genet, Boston, MA 02111 USA
Slonim, Donna K.
[2
,3
]
Koide, Keiko
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Floating Hosp Children, Tufts Med Ctr, Dept Pediat, Div Genet, Boston, MA 02111 USAFloating Hosp Children, Tufts Med Ctr, Dept Pediat, Div Genet, Boston, MA 02111 USA
Koide, Keiko
[1
]
Johnson, Kirby L.
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Floating Hosp Children, Tufts Med Ctr, Dept Pediat, Div Genet, Boston, MA 02111 USAFloating Hosp Children, Tufts Med Ctr, Dept Pediat, Div Genet, Boston, MA 02111 USA
Johnson, Kirby L.
[1
]
Tantravahi, Umadevi
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Women & Infants Hosp Rhode Isl, Dept Pathol, Providence, RI 02905 USAFloating Hosp Children, Tufts Med Ctr, Dept Pediat, Div Genet, Boston, MA 02111 USA
Tantravahi, Umadevi
[4
]
Cowan, Janet M.
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Floating Hosp Children, Tufts Med Ctr, Dept Pediat, Div Genet, Boston, MA 02111 USAFloating Hosp Children, Tufts Med Ctr, Dept Pediat, Div Genet, Boston, MA 02111 USA
Cowan, Janet M.
[1
]
Jarrah, Zina
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Floating Hosp Children, Tufts Med Ctr, Dept Pediat, Div Genet, Boston, MA 02111 USAFloating Hosp Children, Tufts Med Ctr, Dept Pediat, Div Genet, Boston, MA 02111 USA
Jarrah, Zina
[1
]
Bianchi, Diana W.
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Floating Hosp Children, Tufts Med Ctr, Dept Pediat, Div Genet, Boston, MA 02111 USAFloating Hosp Children, Tufts Med Ctr, Dept Pediat, Div Genet, Boston, MA 02111 USA
Bianchi, Diana W.
[1
]
机构:
[1] Floating Hosp Children, Tufts Med Ctr, Dept Pediat, Div Genet, Boston, MA 02111 USA
[2] Tufts Univ, Sch Med, Dept Pathol, Boston, MA 02111 USA
[3] Tufts Univ, Dept Comp Sci, Medford, MA 02155 USA
[4] Women & Infants Hosp Rhode Isl, Dept Pathol, Providence, RI 02905 USA
To characterize the differences between second trimester Down syndrome (DS) and euploid fetuses, we used Affymetrix microarrays to compare gene expression in uncultured amniotic fluid supernatant samples. Functional pathway analysis highlighted the importance of oxidative stress, ion transport, and G protein signaling in the DS fetuses. Further evidence supporting these results was derived by correlating the observed gene expression patterns to those of small molecule drugs via the Connectivity Map. Our results suggest that there are secondary adverse consequences of DS evident in the second trimester, leading to testable hypotheses about possible antenatal therapy for DS.
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页码:9425 / 9429
页数:5
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