Inhibition of inducible nitric oxide synthase by acetamidine derivatives of hetero-substituted lysine and homolysine

被引：66

作者：

Young, RJ ^{[1
]}

Beams, RM ^{[1
]}

Carter, K ^{[1
]}

Clark, HAR ^{[1
]}

Coe, DM ^{[1
]}

Chambers, CL ^{[1
]}

Davies, PI ^{[1
]}

Dawson, J ^{[1
]}

Drysdale, MJ ^{[1
]}

Franzman, KW ^{[1
]}

French, C ^{[1
]}

Hodgson, ST ^{[1
]}

Hodson, HF ^{[1
]}

Kleanthous, S ^{[1
]}

Rider, P ^{[1
]}

Sanders, D ^{[1
]}

Sawyer, DA ^{[1
]}

Scott, KJ ^{[1
]}

Shearer, BG ^{[1
]}

Stocker, R ^{[1
]}

Smith, S ^{[1
]}

Tackley, MC ^{[1
]}

Knowles, RG ^{[1
]}

机构：

[1] Glaxo Wellcome Res & Dev Ltd, Stevenage SG1 2NY, Herts, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 06期

关键词：

D O I：

10.1016/S0960-894X(00)00055-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and in vitro evaluation of the acetamidine derivatives of hetero-substituted lysine and homolysine analogues have identified potent inhibitors of human nitric oxide synthase enzymes, including examples with marked selectivity for the inducible isoform. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：597 / 600

页数：4

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