Kinetic resolutions of indolines by a nonenzymatic acylation catalyst

被引：143

作者：

Arp, Forrest O. ^{[1
]}

Fu, Gregory C. ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 44期

关键词：

D O I：

10.1021/ja0657859

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first method for the kinetic resolution of indolines through catalytic N-acylation is described. To improve the selectivity factor, new planar-chiral PPY-derived catalysts were synthesized, wherein the chiral environment was systematically modified. This work provides a rare example of a nonenzyme-based acylation catalyst for the kinetic resolution of amines. Copyright © 2006 American Chemical Society.

引用

页码：14264 / 14265

页数：2

共 27 条

[1]

ANSLYN EV, 2006, MODERN PHYS ORGANIC, P277

[2]

Arai S, 2001, ANGEW CHEM INT EDIT, V40, P234, DOI 10.1002/1521-3773(20010105)40:1<234::AID-ANIE234>3.0.CO

[3]

2-K

[4] Tuning the enantioselective N-acetylation of racemic amines: A spectacular salt effect [J].