Laminar and compartmental regulation of dendritic growth in mature cortex

被引：94

作者：

Chow, David K. ^{[1
]}

Groszer, Matthias ^{[2
]}

Pribadi, Mochtar ^{[3
]}

Machniki, Michal ^{[4
]}

Carmichael, S. Thomas ^{[4
]}

Liu, Xin ^{[3
]}

Trachtenberg, Joshua T. ^{[1
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurobiol, Los Angeles, CA 90095 USA

[2] Univ Paris 06, Inst Fer Moulin, INSERM, U839, F-75005 Paris, France

[3] Univ Calif Los Angeles, David Geffen Sch Med, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA

[4] Univ Calif Los Angeles, David Geffen Sch Med, RNRC, Dept Neurol, Los Angeles, CA 90095 USA

来源：

NATURE NEUROSCIENCE | 2009年 / 12卷 / 02期

关键词：

IN-VIVO; PLASTICITY; NEOCORTEX;

D O I：

10.1038/nn.2255

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Can dendrites grow in mature cortex? We used chronic in vivo imaging to follow pyramidal neurons before and after cortical deletion of the Pten tumor suppressor gene in mature mice. We found that Pten/mTOR signaling uniquely regulates the growth of layer 2/3 apical dendrites; no effects of gene deletion were observed on basal dendrites of these pyramidal neurons or along layer 5 apical dendrites.

引用

页码：116 / 118

页数：3

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