Loss of autoreceptor functions in mice lacking the dopamine transporter

被引:190
作者
Jones, SR
Gainetdinov, RR
Hu, XT
Cooper, DC
Wightman, RM
White, FJ
Caron, MG
机构
[1] Duke Univ, Med Ctr, Dept Cell Biol, Howard Hughes Med Inst, Durham, NC 27710 USA
[2] Finch Univ Hlth Sci Chicago Med Sch, N Chicago, IL 60064 USA
[3] Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA
[4] Univ N Carolina, Curriculum Neurobiol, Chapel Hill, NC 27599 USA
关键词
D O I
10.1038/10204
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Autoreceptors provide an important inhibitory feedback mechanism for dopamine neurons by altering neuronal functions in response to changes in extracellular levels of dopamine. Elevated dopamine may be a component of several neuropsychiatric disorders. However, evidence concerning the state of autoreceptors in such conditions has remained elusive. The function of dopamine autoreceptors was assessed in mice lacking the dopamine transporter (DAT). Genetic deletion of the DAT gene in mice results in a persistent elevation in levels of extracellular dopamine. Direct assessment of impulse-, synthesis- and release-regulating autoreceptors in these mice reveals a nearly complete loss of function. These findings may provide insight into the neurochemical consequences of hyperdopaminergia.
引用
收藏
页码:649 / 655
页数:7
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