Laser-induced release of encapsulated materials inside living cells

被引：402

作者：

Skirtach, Andre G.

Javier, Almudena Munoz

Kreft, Oliver

Koehler, Karen

Alberola, Alicia Piera

Moehwald, Helmuth

Parak, Wolfgang J.

Sukhorukov, Gleb B.

机构：

[1] Max Planck Inst Colloids & Interfaces, Inst Grenzflachen, D-14424 Potsdam, Germany

[2] Univ Munich, Ctr NanoSci, D-80799 Munich, Germany

[3] Queen Mary Univ London, IRC, Dept Mat, London E1 4NS, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 28期

关键词：

drug delivery; multilayers; nanoparticles; photoactivation; polymers;

D O I：

10.1002/anie.200504599

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Escape route: The laser-initiated release of fluorescently labeled polymers from polyelectrolyte-multilayer microcapsules is demonstrated inside living cancer cells. A polymer is incorporated in capsules with metal nanoparticles in their walls, which serve as light-absorbing centers. The capsules are internalized by cells and near-infrared light ruptures the walls of the capsules, thus releasing the content into the cells. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：4612 / 4617

页数：6

共 136 条

[31] The dawning era of polymer therapeutics [J].