Platelet anti-aggregating triterpenoids from the leaves of Acanthopanax senticosus and the fruits of A-sessiliflorus

被引：43

作者：

Jin, JL ^{[1
]}

Lee, S ^{[1
]}

Lee, YY ^{[1
]}

Kim, JM ^{[1
]}

Heo, JE ^{[1
]}

Hye, SYC ^{[1
]}

机构：

[1] Seoul Natl Univ, Inst Nat Prod Res, Seoul, South Korea

来源：

PLANTA MEDICA | 2004年 / 70卷 / 06期

关键词：

D O I：

10.1055/s-2004-827159

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Six triterpenoids, chiisanogenin, chiisanoside, ursolic acid, oleanolic acid, beta-sitosterol and daucosterol, were isolated as the platelet anti-aggregating components from the leaves of Acanthopanax senticosus and the fruits of A. sessiliflorus. Chiisanogenin showed about 50-fold higher potency than acetylsalicylic acid (ASA) on U46619-induced platelet aggregation (IC50: 6.21 muM) and 10-20-fold higher effects than ASA on epinephrine- and arachidonic acid (AA)-induced aggregation (IC50: 2.50 and 4.81 muM, respectively).

引用

页码：564 / 566

页数：3

共 13 条

[1] Chandra Shekhar M., 1981, Vac News, V12, P12
[2] HAHN DR, 1984, CHEM PHARM BULL, V32, P1244
[3] Phytochemical constituents from the fruits of Acanthopanax sessiliflorus
Lee, S
Kim, BK
Cho, SH
Shin, KH
[J]. ARCHIVES OF PHARMACAL RESEARCH, 2002, 25 (03) : 280 - 284
[4] Antibacterial compounds from the leaves of Acanthopanax senticosus
Lee, S
Shin, DS
Oh, KB
Shin, KH
[J]. ARCHIVES OF PHARMACAL RESEARCH, 2003, 26 (01) : 40 - 42
[5] C-13 NMR-SPECTRA OF PENTACYCLIC TRITERPENOIDS - A COMPILATION AND SOME SALIENT FEATURES
MAHATO, SB
KUNDU, AP
[J]. PHYTOCHEMISTRY, 1994, 37 (06) : 1517 - 1575
[6] McNicol A., 1996, PRACT APPROACH SER, P1
[7] Antiplatelet activities of aporphine alkaloids isolated from leaves of Magnolia obovata
Pyo, MK
Yun-Choi, HS
Hong, YJ
[J]. PLANTA MEDICA, 2003, 69 (03) : 267 - 269
[8] Platelet function assays
Rand, ML
Leung, R
Packham, MA
[J]. TRANSFUSION AND APHERESIS SCIENCE, 2003, 28 (03) : 307 - 317
[9] 220-MHZ NMR-SPECTRA OF PHYTOSTEROLS
RUBINSTEIN, I
GOAD, LJ
CLAGUE, ADH
MULHEIRN, LJ
[J]. PHYTOCHEMISTRY, 1976, 15 (01) : 195 - 200
[10] Lupane triterpenoid glycosyl esters from leaves of Acanthopanax divaricatus
Shirasuna, K
Miyakoshi, M
Mimoto, S
Isoda, S
Satoh, Y
Hirai, Y
Ida, Y
Shoji, J
[J]. PHYTOCHEMISTRY, 1997, 45 (03) : 579 - 584

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